Rebecca Dekker

Rebecca Dekker

PhD, RN

Sara Ailshire

Sara Ailshire

MA, PhD

Evidence on: Inducing at 41 Weeks
or Later 

Published in 2015, and most recently updated on April 1, 2026, by Rebecca Dekker, PhD, RN and Sara Ailshire, PhD. All Rights Reserved. Please read our Disclaimer and Terms of Use. For a printer-friendly PDF, become a Professional Member to access our complete library.

Podcast Transcript

Dr. Rebecca Dekker – 00:00:00:

Hi everyone. On today’s podcast, we’re going to talk about the evidence on inducing labor at 41 weeks or later. Welcome to the Evidence Based Birth® Podcast. My name is Rebecca Dekker, and I’m a nurse with my PhD and the founder of Evidence Based Birth®. Join me each week as we work together to get evidence-based information into the hands of families and professionals around the world. As a reminder, this information is not medical advice. See ebbirth.com/disclaimer for more details. Hi, everyone. Today, I am so excited to bring you today’s podcast all about the evidence on induction of labor at 41 weeks or later. 

So today, along with my co-host, Dr. Sara Ailshire, we have a lot of brand new evidence-based information to bring to you. So Sara is a member of the EBB research team, and she has come onto the podcast many times to share her research updates. And today, Dr. Sara is here to talk about our latest Signature Article, all about the research on inductions at late term and further beyond in pregnancy. So this episode is a companion podcast episode to our earlier podcast on the evidence, “What is a Due Date,” episode 384, which came out in January of 2026. So Sara, welcome back to being a co-host on the podcast with me.

Dr. Sara Ailshire – 00:01:29:

Hi, thank you so much for having me back on. It’s always good to be back and get on the pod and talk about what we’ve been up to. So I’m really excited to talk about everything that we’ve added to this article, the latest research on the topic, and to finish up our two-part series about due dates and induction at 41 weeks and beyond. So we’ve been working on these for a really long time. And now that we’re recording this podcast, it means that we’re at the finish line. It’s always a great feeling when these big projects come to an end and we get to share what we’ve learned with everybody.

Dr. Rebecca Dekker – 00:01:59:

Yes. And now all this work that we’ve put into the many hours you’ve put in, I’ve been helping edit. We get to the point where we can share it with everyone. And we love being able to share the evidence with you. So if you want any of the materials or scientific references that go along with this episode, it’s super simple to access. Just go to ebbirth.com/inducingduedates. And everything there is waiting for you. So just to rewind a little bit, I originally published the Evidence on Due Dates here at Evidence Based Birth® in the year 2015. And then we updated that article in 2020. And we now have a lot of new content here at Evidence-Based Birth about due dates and induction. I want to point out that in the past, we called this Signature Article the evidence on inducing for due dates. But we’re changing the title of this article to the evidence on inducing for 41 weeks or later. And that’s because after the 39-week time point, which we cover in a separate podcast and article all about the ARRIVE Trial, 41 weeks or one week past your due date is the next time point that researchers focus on. There is surprisingly very little research about being induced for your actual due date of 40 weeks. But there’s been a ton of research recently on being induced at 41 weeks. And so that’s why we’re focusing on 41 weeks in the Signature Article and on this podcast. As a content note, in this episode, we will discuss the risk of stillbirth, which is the loss of a baby at or beyond 20 weeks of pregnancy. We will also talk about the risk of newborn death. Stillbirth and newborn loss touches the lives of many parents, birth workers, and providers all around the world. And in the show notes, we will share some resources that honor the babies lost and support parents and families affected by this type of loss. Now, last time on the podcast, when Dr. Sara was here, we talked about the science behind due dates so we could understand where that 40-week number comes from, what that estimate gets right and gets wrong. We also talked a little bit about why providers may get concerned when a pregnancy goes past term or past the due date. In this episode, we’re specifically focusing on 41 weeks, which is one week past the due date. And we’re going to also focus on why providers might recommend or at least start talking about inducing at 41 weeks once you’ve gone past your due date. So if you’re pregnant or you’re hoping to become pregnant and you want to learn more about what to expect, if you go past your due date, or if you’re a birth worker, maybe a doula, childbirth educator, your clients have questions about induction at the end of pregnancy, especially if they really wanted to go into labor on their own. Hopefully today we can help you out. We want to cover why someone might start hearing from providers that they need to be induced after they go past their due date, the difference between a medically indicated induction and an elective induction. We’re going to talk a lot about what the research says, what the health outcomes are when labor is induced at 41 weeks instead of waiting for labor to begin on its own, which is also called expectant management. We are going to summarize the benefits and the risks of induction at 41 weeks and beyond. And we’re going to talk about what the professional guidelines say on this topic. We’re going to answer some frequently asked questions about these topics. And of course, we’ll end by giving you the bottom line. So, Sara, can you start us off by explaining how common is it for someone to be induced for going past their estimated due date?

Dr. Sara Ailshire – 00:05:58:

Yeah, that’s a great question. That’s where we start in the article. In 2022, which is some of the most recent data that we have, the total induction rate in the United States was 31.8%. And this comes from a review of American birth certificate data that was published in 2024. But that number might be inaccurate because research suggests that induction of labor is probably underreported in the federal vital statistics that we get so much of our information about pregnancy, childbirth, and birth outcomes from. Also, specific details about induction are not recorded in standard U.S. birth certificate data. So we cannot know for sure how often people may have different types of inductions or why inductions are carried out, for example. However, there are researchers who are trying to help answer this question. We do know, for example, that 40% of participants in the Listening to Mothers in California survey that was published in 2018 reported that their care provider tried to induce their labor. The researchers then were able to ask the participants in the study for the reasons why they were induced. And two of the most common reasons for induction were, one, out of everybody who was induced, 35% of those said that they were induced because their baby was full term. And close to the due date. And then another 22% of those who said that they were induced said that they were induced because their healthcare provider was concerned that they were overdue. So induction can be a really helpful tool if there’s something that’s happening in pregnancy that can put the parent or the baby at risk. I think I’ve told my story on the podcast before I was induced for preeclampsia, for example, and I’m really grateful that, you know, I got the care I needed to have a healthy birth and, you know, be doing well today. And there’s some people who choose induction for themselves at term. They think it’s the best option for them. They’re ready, you know, it’s their free choice. However, in the research from Listing the Mothers in California data that we have, we see that some providers consider being overdue or being past your due date, a medical reason for why somebody might need an induction.

Dr. Rebecca Dekker – 00:08:09:

Yeah, while you were talking, it’s reminding me of how frustrated you and I were at trying to find information on how often labor is induced for going past the due date, because it seems like it’s something that we don’t really have documented anywhere, at least on a national basis. And I know we were able to look at a few countries, but worldwide, it just seems like we’re just kind of guessing how often induction happens for going past your due date. We get a lot of comments from doulas in particular who say like almost all of my patients are getting pressure to be induced at 39, 40 or 41 weeks. And I’m just affirming that this was a difficult subject to find data on.

Dr. Sara Ailshire – 00:08:49:

Yeah, absolutely. You know, we can find information about induction, even if that information, which like other researchers have documented, might be a little bit imperfect. But you know, if we had our wish list of all the data that we could have, it’d be really nice to have a little bit more insight into this and be able to really understand, you know, do people’s experiences, like birth professionals experiences, does that align with, you know, what the numbers are, but we don’t have them. So Rebecca, would you mind walking us through the distinction between a medically indicated induction and an elective induction when it comes to going past your due date?

Dr. Rebecca Dekker – 00:09:25:

Yeah. So you mentioned having a medically indicated induction a few minutes ago. So in general, inductions are considered to be medically indicated when there are medical problems or pregnancy complications present that make it less safe to continue the pregnancy. Medically indicated inductions typically refer to inductions where the motivation for attempting to induce labor is either to respond to a medical condition that could threaten your health or the well-being of your baby or a situation where giving birth could help resolve a medical condition before it becomes worse, such as with preeclampsia. So medically indicated inductions can happen anytime during pregnancy. They can happen well before your due date. If there’s a medical indication, it can even happen before viability or the age where a fetus can be born and have a chance of surviving outside the womb. So we do have a reference list and you can access that for descriptions of medical conditions in which preterm or early term birth via induction and or Cesarean may be recommended by providers. So, you know, we can have medical complications that maybe call for an induction all the way to like, we need this induction to save your life and everything in between. Now, labor inductions that do not have a clear medical reason or indication for taking place are called elective inductions. So elective inductions might occur for preference reasons or for social reasons. If you or your healthcare provider want the birth to happen when a specific provider is on duty, for example, or maybe you need to schedule the birth around the availability of a partner or support person. Maybe they’re about to be deployed and you want to have the baby before they leave. Inductions that are elective might also occur for reasons like wanting to be done with an uncomfortable pregnancy, or maybe you live a long distance from the hospital. So you feel like it’s safer to induce rather than risk going into labor and having the baby in the car on the way there. Or maybe there’s an upcoming blizzard or hurricane, or you’re trying to plan care around other children or dependents. So there are a lot of reasons why someone might choose an elective induction. Now, opinions can differ on, you know, what is the best, most inclusive term to use when we’re referring to inductions that don’t have a clear medical indication, including when inductions are done for reaching your due date. So there is controversy over what would we call an induction simply for reaching 41 weeks, for example. So in the Signature Article, we chose to use the term elective induction when we’re talking about situations like that, that don’t have a clear medical indication, because it’s the term most commonly used in research. And we’re writing about this topic for a general audience. And we also try to use the terms that researchers use to ensure we’re accurately representing their work. So in the United States, elective inductions typically do not occur earlier than 39 weeks and zero days. And this is sometimes referred to as the 39-week rule. And that’s because in 2009, there was a set of guidelines published by the American College Obstetricians and Gynecologists known as ACOG and the Society for Maternal and Fetal Medicine, where they advised against elective inductions prior to 39 weeks of pregnancy due to the known increased risk of complications for infants who are born in that early term period between 37 weeks, zero days and 38 weeks, six days. But sometimes the lines between an elective versus a medically indicated induction are blurred and not always clear. So some providers consider being induced for late term pregnancy, which is considered 41 weeks, zero days to 41 weeks, six days, or post term pregnancy, which is considered to be 42 weeks, zero days and later to be medically indicated because of the increased risk of complications that come with longer pregnancies. While others might refer to it as an elective induction if there are no existing health problems at that time. And as I mentioned earlier, to stay consistent, and because this is what the term most of the researchers use, we will call those inductions at 41 and 42 weeks when there’s no other health problems, we’ll call those elective inductions. Now, when someone gets closer or past their due date, they might start facing that question. Should we induce labor or should we wait for labor to start on its own? Or maybe you don’t want to wait forever, but you’re willing to wait just a few more days or maybe one more week. Another way of referring to waiting for labor to start on its own, usually with fetal monitoring to monitor the baby’s status is called expectant management. And expectant management can sometimes result in spontaneous labor where you went into labor on your own, and it can sometimes result in choosing an elective induction later or having a medically indicated induction later. That is often compared in the research with a more active management style where labor is induced electively for getting close to reaching or passing the due date without any other health problems indicating a need for induction. So there is a lot of research comparing the benefits and risks of this more active management style using an elective induction at certain time points versus expectant management. And that research kind of spans the length of time from 39 weeks to 42 weeks and beyond. So, Sara, I think now let’s turn to that research. You know, what does the research say about outcomes when labor is induced primarily at 41 weeks? Because that’s what we’re going to focus on today in this podcast. Instead of waiting for labor to begin on its own.

Dr. Sara Ailshire – 00:15:24:

Absolutely. So before we get into that, though, I wanted to talk a little bit about some of the limits of the research evidence that we have that compares induction at 41 or 42 weeks with waiting for labor to start on its own. And just as a disclaimer, research is not a perfect process. And the fact that we can talk about some of these issues from previous research studies means that researchers know about this and can account for this in future studies as they design new randomized controlled trials or as they study existing medical records doing observational research. So we have identified four of these things to keep in mind. First, many of the clinical trials on induction versus expectant management were carried out in countries or during time periods with comparatively lower Cesarean rates than you might find in another country or today, depending where you are in the world. These research findings on Cesarean rates and inductions might not apply, you know, to people who are giving birth in hospitals that have high Cesarean rates. You know, the setting of birth would matter a lot. And if you’re giving birth in a hospital, that puts a really strict time limit on the length of labor that discourages mobility and position changing. Or, you know, if you have epidural doesn’t provide assistance with, you know, moving you around as you might need, you might have a very different experience with an induction than somebody who’s induced in a hospital where birthing people have freedom of movement. They’re able to rest. There’s greater shared decision making. We hope that research is sort of like generally applicable. That’s the goal. But circumstances can matter and can maybe impact how applicable, you know, a study might be to your circumstances. Another limitation is that the correct comparison group for elective induction includes people who are induced later in pregnancy, as well as those who go into labor spontaneously. Most researchers, though, only report the results of the two study groups as they originally are defined or as people are originally assigned. Those who are meant to have the management or the induction versus those who are meant to have expected management. But it can be more helpful to look at the results for people who were actually induced or who actually went into spontaneous labor. 

For example, in the Signature Article, we spend some time talking about an older study from the 1990s, the Hanna Post-Term Trial, which is a very important research study, even though I think it’s like over 30 years old at this point. Even saying it remains one of the biggest studies about induction for reaching 42 weeks. In this trial, about one third of mothers who were assigned to the induction group went into labor spontaneously before the induction. So when you look at the breakdown of what actually happened to the people in the two research groups, as we do in the article, it becomes apparent that the Cesarean rates only increased with expected management when induction occurred in the pregnancy later and not when mothers went into spontaneous labor later in the pregnancy. The third thing to consider is that in most studies, people in the expected management group have more fetal testing while they’re waiting for labor to begin. And some of these tests might have shown possible signs of distress. And some of those results could have been false positives. So extra fetal testing could possibly lead to higher rates of Cesarean for suspected fetal distress during labor in an expected management group. And the last point to consider is that induction protocols can vary from study to study, and sometimes they can even vary within the studies themselves. So this was another issue in the Hannah Post-Term study. People in the active management group first received drugs to ripen their cervix and then got drugs to induce labor, while the people in the expected management group who ended up with an induction did not have cervical ripening. So it’s known that if you have an induction without cervical ripening, you are more likely to have a Cesarean as an outcome. So in this case, the expected management group would have been at increased risk of Cesarean compared to the active management group.

Dr. Rebecca Dekker – 00:19:27:

Yeah. So you mentioned the Hannah Post-Term trial that came out in the 1990s that had a really big impact. I think people used to think you just let people go on as long, you know, they’ll go into labor when they go into labor and you shouldn’t really induce them. And then after the Hannah Post-Term trial, the 42-week point kind of became the point that everybody was like, all right, this is where it’s safer to be induced. And there are some limitations, as you mentioned, to the Hannah Post-Term trial, and you can learn more about it in the Signature Article. But then what happened next was in the late 2010s, there were two big trials that came out of Northern Europe on the 41-week time point. There was INDEX that was published out of the Netherlands and SWEPIS from Sweden. So, Sara, should we start with kind of breaking down the INDEX trial?

Dr. Sara Ailshire – 00:20:18:

Yeah, absolutely. So the INDEX trial is named for the acronym that the researchers used to stand in for the full title of their study, which was Induction at 41 Weeks, Expectant Management at 42 Weeks, so INDEX. This was a multi-center trial that was conducted at 123 midwifery practices in 45 hospitals in the Netherlands, where midwives are lead professionals for most pregnancies and births. The researchers randomly assigned a total of 1,801 pregnant people to either being induced at 41 weeks and 0 to 1 days. Or to expected management and then an induction if needed at 42 weeks and zero days, if labor had not started on its own by that point. In the Netherlands, at least at the time of the study, labor is not usually induced before 42 weeks with an uncomplicated pregnancy. So they were able to get the ethical approvals they needed to conduct a study. In the U.S., for example, it is not standard practice in many practices to continue expected management for as long as 42 weeks. So it might have been more difficult to get the same ethical approvals needed to do that study here, for example. Pregnant people were enrolled into the study between 2012 and 2016. The mothers had to be healthy and pregnant with single head down babies. Everybody had to have a gestational age that was estimated with ultrasound before 16 weeks of pregnancy to ensure that they had the most accurate estimate of how far along they were in their pregnancy. They excluded anybody from the trial who had a previous Cesarean, who had a high blood pressure disorder, who had expected or known problems with the baby’s growth, whose baby had an abnormal fetal heart rate, or where there were known fetal malformations or other known complications of the pregnancy. In both of the research groups, cervical ripening and induction methods depended on local protocols. So thinking back to some of the issues we talked about in research, this is one that continued. It’s an important weakness in the INDEX study because, again, like that big Hannah Post-Term trial, individual providers in the INDEX trial might have managed labor inductions differently depending on group assignment. The variation in induction methods used in the study also limits the study’s generalizability or the ability to apply the results to the population at large, since care providers lack an induction protocol that they could replicate, that they could kind of follow to hopefully see the same results. In the elective induction group, 29% of the participants had spontaneous labor before their induction, and 71% were induced. In the expected management group, 74% of the participants had spontaneous labor before their planned induction, and 26% were induced. Interestingly, the median decrease in length of pregnancy between the two groups was only two days. So, in other words, the median pregnancy was only two days shorter in the elective induction group compared to the expected management group.

Dr. Rebecca Dekker – 00:23:25:

I always find that fascinating when they’re like, this group is going to be induced and then this group is going to have expectant management and it’s supposed to be a week’s difference, but it’s just really two days. So we’re looking at the difference of average pregnancy length of like, what does it do when you make a pregnancy two days shorter at this time point? So what do they find?

Dr. Sara Ailshire – 00:23:48:

Yeah. So for the mothers, the findings were that there’s no difference in Cesarean rates across the two groups. It was about 11% of birthing people in each group had a Cesarean. There was also no difference in combined measure of bad outcomes for mothers. It was about 11 to 14% in both groups. This outcome was called by the researchers, the maternal composite adverse outcome rate. And what they did was they grouped a bunch of negative outcomes that you would hope not to see together. You know, I mean, they also looked at those outcomes individually, but they put them in a group together just to see sort of generally what were these undesirable outcomes that happened. In total, and these included excessive bleeding after birth or requiring a manual removal of the placenta, severe tears or admission to the intensive care unit, or maternal death. There were no maternal deaths that occurred in either group in the study, and the researchers did not report on the rate of uterine rupture in either group. The other major outcome they looked at were how were things for the babies? So babies in the elective induction group had a lower composite adverse outcome rate of 1.7% in the induction group versus 3.1% in the expectant management group, and this combined negative outcome, same thing as, same sort of name as for the mothers, but included different negative outcomes, and these were perinatal death, an APGAR score of less than seven at five minutes, a measure of umbilical blood that identifies there’s a problem of low oxygen, meconium aspiration syndrome, nerve injury, brain bleeds, or admission to the newborn intensive care unit, or NICU. It was mostly the lower rate of APGAR score of less than 7 at 5 minutes that contributed to the lower combined adverse outcome with the elective induction group. 1.2% with the elective induction versus 2.6% with expected management. The researchers noted, though, that there were no difference in rates of APGAR score of less than 4 at 5 minutes. However, the combined outcome was still significantly lower in the elective induction group if using APGAR score of less than 4 at 5 minutes and excluding fetal malformations. There was one stillbirth that occurred in the elective induction group at 40 weeks and six days before the mother was induced. And there were two stillbirths that occurred in the expected management group while the mothers were waiting for labor. One stillbirth was to a first-time mother. It occurred at 41 weeks and three days, and her baby was small for gestational age. The other stillbirth occurred to a woman who had had previous births. It took place at 41 weeks and four days, and her placenta showed signs of infections. There were no newborn deaths in either group. And I should note that this concern about a small for gestational age infant is something that we talked about in the previous podcasts, and we cover it a little bit more in depth in the companion Signature Article on what is a due date. But just for our audience who might not have seen those or might not have listened to the last podcast, when a baby is small for gestational age, meaning that they’re estimated to be at or below the 10th percentile for weight, it doesn’t necessarily mean that something is wrong because sometimes people are small and they have small babies. However, sometimes a baby being very, very small can mean that there’s something that has gone wrong, either due to an underlying genetic condition or another problem in pregnancy, maybe with the placenta or the umbilical cord, that has negatively impacted their growth and could have potentially contributed to their death in utero. And finally, for the group of babies in the study, there was no protocol for fetal monitoring. Like the protocol for induction, it varied from place to place. But in general, fetal monitoring and assessment of amniotic fluid levels was typically performed between 41 and 42 weeks for research participants. So in summary, the INDEX trial found that elective induction at 41 weeks resulted in similar Cesarean rates and fewer overall bad outcomes for babies compared to waiting for labor until 42 weeks. The absolute risk of a bad outcome, a combined measure of perinatal death, intensive care admission, or APGAR score of less than four at five minutes, was low in both groups. 1.7% in the induction group versus 3.1% in the expected management group.

Dr. Rebecca Dekker – 00:28:30:

So has there been any more research about this that’s come out since INDEX?

Dr. Sara Ailshire – 00:28:36:

Yeah, so something else that was interesting was that three years after the INDEX study was published, the researchers also published a companion study in 2022. This companion study was inspired by the fact that not everyone who was asked to participate in the INDEX trial agreed to take part. In fact, about 69% of those who were invited to participate in the trial declined because they did not want to be randomly assigned to one group or the other. So in this companion study, researchers followed the labor and birth outcomes of those who declined to participate in the INDEX trial in order to see if characteristics and health outcomes differed between those who were in the trial versus those who declined to participate. So they looked at people who gave birth at 90 midwifery practices and 12 hospitals in the Netherlands between 2012 and 2016. And they were able to recruit 3,642 women who met the same requirements as those who were enrolled in the INDEX study. And for the purposes of analysis, the participants were grouped into three categories according to their preferences for either one, induction, two, expectant management, or three, if the researchers couldn’t identify a preference. And they called them the unknown preference group.

Dr. Rebecca Dekker – 00:29:52:

So I guess in the study, which was observational, Sara, they’re just trying to observe the outcomes when people fall into one of these groups naturally, either induction at 41 weeks or expectant management up until 42 weeks, correct?

Dr. Sara Ailshire – 00:30:06:

Absolutely. Yeah. And so, and I’ll talk a little bit now about what the researchers found. So for the mothers, they found that the overall C-section rate was 10.5% in the induction group and 8.9% in the expectant management group. And for people who were giving birth for the first time, the Cesarean rate was also lower in the expected management group compared to the induction group. The combined measure of poor health outcomes for mothers was similar in both groups, 11.6% in the induction group versus 11.4% in the expectant management group. And again, this was that same maternal composite adverse outcome rate. One maternal death occurred in the expectant management group from an amniotic fluid embolism. An amniotic fluid embolism is a very rare complication in pregnancy that occurs close to or shortly after birth. When the birthing person’s bloodstream is exposed to amniotic fluid and they have a severe reaction, this type of exposure is really common in pregnancy, especially during late term and birth. There’s all sorts of fluid interchange between a birthing person and a baby. So researchers are trying to understand why this occurs in some people, but it doesn’t occur in most others. Aside from that very serious and tragic outcome, five other women were admitted to the intensive care unit, four from the unknown preference group, and one from the expectant management group. And most of those admissions to the ICU were due to severe postpartum hemorrhage. So for the babies, the findings in this study were that babies in the elective induction group had a lower composite adverse outcome rate of 1.1% versus 1.9% in the expected management group. No stillbirths occurred in this study, while one neonatal death occurred the day of birth in the unknown preference group. And the infant who died was born to somebody who went into spontaneous labor at 41 weeks, two days, and experienced a sudden excessive loss of blood after their water broke. The baby’s heart rate slowed, they had an emergency Cesarean, and the baby died later due to complications of a lack of oxygen. So in summary, this companion study to the INDEX trial found a lower rate of Cesareans for those who chose expectant management. They also observed a similar rate of poor maternal health outcomes with induction versus expectant management. Those who chose an elective induction at 41 weeks had fewer overall adverse outcomes for newborns. However, the absolute risk for adverse newborn outcomes was low in both groups, and interestingly, it was lower than the rates that they observed at the original INDEX trial. So that was the INDEX trial. It was one of the big, important, recent studies that came out on this topic. Rebecca, would you like to walk us through SWEPIS?

Dr. Rebecca Dekker – 00:32:51:

Yeah, so SWEPIS is the other really large randomized control-trial on induction at 41 weeks, and it stands for the Swedish Post-Term Induction Study. S-W-E-P-I-S is the acronym. It gained a lot of media attention when it was published. There were headlines such as Post-Term pregnancy research canceled after six babies die. And, the truth is, you know, there were serious things that happened during this study. The researchers planned to enroll 10,000 mothers from multiple healthcare centers across Sweden, but they ended up stopping the study early with about 1,380 people in each group after their data safety and monitoring board found a significant difference in stillbirths and newborn deaths between groups. So similar to the Netherlands, when INDEX was trialed out, midwives in Sweden at this time did not typically induce labor before 42 weeks and healthy pregnancies. And also like the Netherlands, midwives in Sweden manage most pregnancies and births. So the investigators for SWEPIS wanted to compare elective induction at 41 weeks and zero to two days versus expectant management and induction at 42 weeks and zero to one day if the person still had not gone into labor. So they enrolled mothers between 2015 and 2018. Being in the study, you had to be healthy, pregnant with a single head down baby. And gestational age was required to be estimated with an ultrasound from the first or second trimester. They excluded lots of people such as those with prior Cesarean or those who had complications such as diabetes, high blood pressure, small for gestational age babies and other complications. So because the stillbirth rate in Sweden is so low, they typically have really good outcomes there. They thought they would need about 10,000 people overall to see a difference in these two interventions, but they ended up not needing that many people to see a difference in outcomes. And that’s why the study was stopped early. So a big strength of the SWEPIS trial is that they did define their induction protocol and they use the same protocol in both groups. So if you had an induction in the elective induction group or in the expectant management group, you would have similar protocols for the induction. And that included if your cervix was already ripened and ready for labor, then they would simply break your water and start synthetic oxytocin, aka pitocin. If your cervix was not ripe or your baby’s head was not engaged, then they would do cervical ripening first. They might use mechanical methods or medications, and then they would give the synthetic oxytocin after the cervix was ripened. So in the elective induction group, the people who are supposed to have that induction, 14% did go into labor on their own before their scheduled induction, and 86% actually had the induction. And in the expectant management group, 67% went into labor spontaneously before their planned induction date and 33% were induced. So similar to the INDEX trial, the median decrease in the length of pregnancy between the groups was very short. So pregnancy in the elective induction group was in general only about three days shorter than those who had expectant management.

Dr. Sara Ailshire – 00:36:23:

Oh, wow. That’s so interesting. So like in the INDEX study, the elective induction group gave birth only a few days earlier than average. So Rebecca, what did the SWEPIS investigators find?

Dr. Rebecca Dekker – 00:36:35:

So as I mentioned earlier, the study was stopped early. There were five stillbirths and one early newborn death in the expectant management group out of 1,379 participants in that group. That gives us a death rate of 4.4 deaths per 1,000 deliveries. In contrast, there were zero deaths in the elective induction group out of 1,381 participants in that group. All five of the stillbirths in the expectant management group occurred between 41 weeks, two days, and 41 weeks, six days. Three of those five stillbirths had no known explanation. One stillbirth had a baby who was small for gestational age, which we already discussed can be a risk factor for stillbirth. And the other stillbirth was a baby who had a heart birth defect. And then the one newborn death occurred four days after birth due to multiple organ failure and a baby who was born large for gestational age. So the authors were trying to kind of talk about what happened here. And they mentioned that, you know, when there might be complications present in the pregnancy, maybe something with the placenta or the umbilical cord, that those differences might become increasingly important as the days of pregnancy progress past 41 weeks, leading to that higher death rate with expectant management past the 41-week time point. And another thing to note is that all of these perinatal deaths, all of these losses were babies who are being born to first-time mothers, which suggests that a 41-week induction might be especially beneficial if you’re giving birth to your first baby. And they calculated that it would take only 230 elective inductions at 41 weeks to prevent one stillbirth or newborn death. And this is a much lower number than previously thought. It doesn’t take as many inductions to save one life. Now, I know, Sara, when you were talking about the INDEX trial, they did not find a significant difference in perinatal death between the induction group and the expectant management group. And I think some of the reasons why they did see a difference in SWEPIS is SWEPIS was a larger study, so it’s better able to detect rare outcomes such as death. And it also could be that in the INDEX trial, they had better fetal monitoring going on during that 41-week time period when people were waiting up until 42 weeks to have their baby, possibly leading to fewer perinatal deaths. It can’t be certain because there were no published fetal monitoring protocols in either trial. Finally, the participants in the SWEPIS expectant management group tended to give birth a little bit later than the participants in the INDEX expectant management group, and that might help explain the higher perinatal death rate in SWEPIS. When they looked at the combined perinatal outcome of severe health outcomes in babies or death, there was no significant difference between the two groups. It was about 2.2 to 2.4% in both groups. However, there was that significant difference in just looking at the death rate. The elective induction group babies were less likely to be admitted to the NICU, 4% versus 5.9%, had fewer cases of jaundice, 1.2% versus 2.3%, and there were fewer big babies in the elective induction group, 4.9% versus 8.3%. For mothers in SWEPIS, there was no meaningful difference in Cesarean rates between groups. It was about 10% to 11% in both groups. More mothers in the elective induction group had a type of infection called endometritis, which is inflammation of the inner lining of the uterus. That was 1.3% versus 0.4%. Meanwhile, there were more mothers in the expectant management group that developed high blood pressure disorders at the end of pregnancy, 3% versus 1.4%. There were no cases of uterine rupture in either group. And when they asked people about their experiences, they found that people in the expectant management group struggled more with negative thoughts. They described feeling in limbo or kind of stuck while they waited for labor or 42-week induction. And as I mentioned, the fetal monitoring in SWEPIS was done per local guidelines because there was no published study protocol for how to monitor the fetus while you’re waiting for labor. However, the mothers recruited in the Stockholm region of Sweden, which was about half the people in the study, did have a specific protocol because that’s what was typically done in that area where they measured amniotic fluid volume and abdominal diameter right at 41 weeks. And that assessment was not really done in the other parts of the country where the study was taking place. And so important to note from the study is that none of the six deaths occurred in the Stockholm region of Sweden where they were doing this type of prenatal fetal monitoring. So this could mean that the results of this study might not apply equally to a place that’s doing more intensive fetal monitoring to make sure everything’s okay with the fetus while you wait for labor to begin. Also, since all of the perinatal deaths were happening in cases where it was a first-time birth and the mother had not given birth before, the study results might not apply to those who have given birth before.

Dr. Sara Ailshire – 00:41:59:

Yeah, I thought the results of this study were really interesting. And of course, it garnered so much attention for some of the outcomes that occurred. Could you share with the listeners what, if any, impact the study had on induction of labor in the country where the study took place, Sweden?

Dr. Rebecca Dekker – 00:42:17:

Yeah. So there has been follow-up research on induction in Sweden after SWEPIS, on this really ignited debate in Sweden, but also in other places around the world about, you know, when should we induce labor? Is this 41 week time point really important? And in Sweden, they changed their guidelines to recommend an induction at 41 weeks to offer that to everyone or to have an individual plan aiming at birth or inducing labor by 42 weeks. And so there was a study published in 2025 comparing outcomes like pre and post these guidelines change. So they looked at all of the births that happened pre-SWEPIS and then all of the births that happened post-SWEPIS. And they were primarily interested in rates of stillbirth and newborn death, as well as overall other bad health outcomes for babies and Cesarean rates. Overall, they found that the risk of stillbirth and newborn death to babies born at or beyond 41 weeks decreased from pre-SWEPIS to post-SWEPIS from about 1.7 per 1,000 infants down to 0.9 per 1,000 infants. And there were also lower rates of birth trauma and a lower risk of stillbirth and newborn death for babies who were born in the 39 to 40 week time period. Meanwhile, they did see induction rates go up slightly. The rate of severe tears went down slightly and women’s experiences of childbirth were slightly better post-SWEPIS. So a little bit mixed results, but overall it seemed like this research did translate into better outcomes for babies after the guidelines were changed. So we’ve gone over INDEX and SWEPIS and some of like the results we’ve seen from those major studies and their follow-up studies. There are also a few other smaller studies that you can see if you review the full Signature Article, as well as a table in the Signature Article that kind of goes over each of the individual studies. So if you want to dive in and learn more, all of the data are there for you. So I thought now, Sara, we could go over the benefits and risks of induction focusing at that 41 week time point. And if it’s okay with you, I’ll read the potential benefits and you can share the potential risks. Sound good?

Dr. Sara Ailshire – 00:44:39:

Sounds great.

Dr. Rebecca Dekker – 00:44:40:

Okay. So when we’re looking at scheduling and induction at 41 weeks, the research does show that one of the main benefits is a lower risk of stillbirth, especially among those who have risk factors for stillbirth. One of those risk factors is being pregnant with your first baby. And the overall or absolute risk of stillbirth is four out of 10,000 pregnancies at 39 weeks, seven out of 10,000 pregnancies at 40 weeks, 17 out of 10,000 pregnancies at 41 weeks, and 32 out of 10,000 pregnancies at 42 weeks. So you can see how that inducing labor closer to that 41 week zero time point would be important because of that increased in risk in the 41st week of pregnancy. Other potential benefits include a lower risk of a baby needing intensive care unit admission, a lower risk of the baby experiencing jaundice, the lower chances of giving birth to a big baby, potentially a lower risk of Cesarean, depending on the practice setting and how well the practitioners do with providing inductions and lowering the risk of Cesarean with inductions. Another consistent finding in the research is that there’s a lower risk of developing a high blood pressure disorder at the end of pregnancy. And cognitive benefits for babies during a continued pregnancy appear to increase until about 40 to 41 weeks of pregnancy. So you’re getting kind of like the full benefit of the baby’s development in the womb if you go up to 41 weeks. And that’s another reason researchers think that is a good time point to go ahead and do an elective induction. And then finally, a lot of people find that a potential benefit for them is the convenience and also the ability to end pregnancy once you’re becoming really uncomfortable. And researchers have found that in general, satisfaction tends to go up when the timing of birth is 41 weeks rather than 42 weeks.

Dr. Sara Ailshire – 00:46:34:

Okay. So those were the pros. And now I’ll talk a little bit about the cons. So some of the cons that we identified from the research was that one, a potential for the medicalization of birth because of the induction. So continuous fetal monitoring, sometimes what people refer to as a cascade of interventions that could occur. Two, the potential for a failed induction leading to a Cesarean. The potential for uterine tachycystole, more than five contractions in 10 minutes average over a 30-minute window, a potential increase in risk of uterine rupture with medical induction, especially among those who have had a previous Cesarean. Missing out on the hormonal benefits of spontaneous labor, increased risk of the mother experiencing the inflammation of the inner lining of the uterus, that endometritis infection that Rebecca referenced earlier. And medically induced contractions can potentially increase pain and make it more likely that a person would choose to also use an epidural.

Dr. Rebecca Dekker – 00:47:37:

Sara, I know you also updated the section on this article about, you know, what did the published guidelines say about induction? Past your due date, can you share some of those guideline recommendations with us?

Dr. Sara Ailshire – 00:47:49:

So for this update, we found recent guideline recommendations about induction at 41 weeks or later from the American College of Obstetricians and Gynecologists, the American College of Nurse Midwives, the Society of Obstetricians and Gynecologists of Canada, the Association of Ontario Midwives, and the National Institute for Healthcare Excellence guidelines in the UK. You can see the actual breakdown by publication in the Signature Article, but the overall trends were that as a pregnancy continues beyond 41 weeks, Most guidelines begin to recommend that providers have discussions with their patients about the benefits and risks of inducing labor versus expected management. They also began to recommend increased fetal monitoring if expected management is chosen at 41 weeks and later. The recommendations for 42 weeks trend towards recommending induction if labor has not yet started on its own. If a patient chooses expected management at 42 weeks or later in pregnancy, recommendations then suggest regular fetal monitoring until birth. Fetal monitoring cannot always prevent complications for occurring, nor will it always catch a complication as it’s happening. But the hope with that recommendation is that providers can interpret these results and share this information with their clients to promote informed choice and to promote shared decision making. So Rebecca, do we have time to do a couple frequently asked questions that we get on this topic?

Dr. Rebecca Dekker – 00:49:18:

Yeah, let’s do two. So one question that comes up on this topic is what about induction for going past your due date in someone who is planning a VBAC? So we hear this a lot, but many people who are planning a vaginal birth after Cesarean or VBAC are told they must go into labor by 39 weeks, or maybe they’re told 40 or 41 weeks, or they’re required to have a repeat Cesarean, or sometimes they’ll say you can have an induction, but not always. Sometimes it’s just you have to have a Cesarean. So researchers have found that only about 10% of people who reach term will spontaneously give birth by 39 weeks and zero days. So if a hospital is mandating, you know, you have to have a repeat Cesarean if you haven’t gone into labor by your 39th week, this means that 90% of people planning a VBAC at that particular facility will be disqualified from having a spontaneous VBAC labor. Also, some hospitals and providers will refuse to provide an induction with VBAC because there is a higher risk of uterine rupture if you have had prior uterine surgery with an induction. So that means some people who reach their required deadline will only have one option, and that’s a repeat Cesarean. There’s actually no evidence supporting these hard stop rules that you must give birth by 39 weeks or you must give birth by 40 weeks if you’re having a VBAC. The first large meta-analysis to specifically look at the link between weeks of pregnancy and likelihood of VBAC was published in 2019. They included 94 observational studies with nearly 240,000 people attempting labor for a VBAC. And interestingly, they found that gestational week at birth was not linked to your odds of having a VBAC. So whether you gave birth at 37 weeks, 39 weeks, or 41 weeks, it didn’t make a difference as to whether someone was having a VBAC or not. And in another study, researchers looked at more than 12,000 people who were electively induced at 39 weeks who were having a VBAC and compared them to those who were having expectant management beyond that date. They found that elective induction at 39 weeks was associated with a higher chance of ending up with a VBAC, 74% versus about 60% for those who had expectant management. But there was also a higher chance of uterine rupture in the elective induction group. So in the induction group, the rate of uterine rupture was 1.4% versus 0.4 to 0.6% in those who chose expectant management. And importantly, the risk of uterine rupture did not go up for those who had expectant management and chose not to be induced. So at 39 weeks during labor, the risk was 0.5%. At 40 weeks, it was 0.6%. At 41 weeks, it was 0.4%. 0.4%, that’s the evidence we have on that. Another question is, are there any benefits to going past your due date? Sara, do you want to take that one?

Dr. Sara Ailshire – 00:52:20:

Yeah. So we talked a little bit about that earlier, but it’s nice to be able to take some more time and really kind of dive in here. So one of the benefits to going past your due date and waiting for spontaneous labor, if that’s your preference, is that you can avoid the potential risks of an induction and associated interventions by having a lower intervention labor and birth. The American College of Obstetricians and Gynecologists, in partnership with the American College of Nurse Midwives, wrote in a committee opinion that titled Approaches to Limit Intervention During Labor and Birth, if you’re interested in looking at it, that some common obstetric practices are of limited or uncertain benefit for low-risk people in spontaneous labor. So if you don’t have an induction, for example, you’re not going to be exposed to certain risks that can come of that particular intervention, like having a failed induction, for example, uterine tachysystole, the uterine contractions are too close together, having an increased need for an epidural, things like that. One of the potential benefit of going past your due date and waiting for spontaneous start of labor is that you might experience hormonal benefits for allowing the normal process of labor to take place. And that’s something that Dr. Sara Buckley covers in her work, The Hormonal Physiology of Childbearing. Based on the available evidence, Dr. Buckley concluded that, quote, Overall, consistent and coherent evidence from physiologic understandings and human and animal studies finds that the innate hormonal physiology of mothers and babies, when it’s promoted, supported, and protected, has significant benefits, both in childbearing, and likely into the future by optimizing labor and birth, newborn transitions, breastfeeding, maternal adaptations, and maternal infant attachment. Also, so another benefit that we’ve heard about anecdotally is that later term and post-term babies have an easier time with breastfeeding. There’s not a lot of research on the subject, but we did find a recent study from New Zealand of around 1,087 women that compared labor and neonatal outcomes based on when an induction took place. You can see the details in the Signature Article, but what they found was that as babies were born later and later, they compared babies born early term, full term, and then late term. So 37 to 38 weeks, 39 to 40 weeks. And then 41 weeks later, the babies born late term, 41 weeks and later, were most likely of the three categories to initiate and sustain breastfeeding. There might also be cognitive benefits for babies when pregnancy is allowed to continue to 40 and 41 weeks. There was one study that we found that showed, again, a progressive benefit in cognitive outcomes several years after birth until 41 weeks. There might also be cognitive benefits for babies when pregnancy continues to 40 or 41 weeks. A study of Scottish schoolchildren found that the need for special education was highest among children born before 37 weeks. And there was a continuous decrease in that need for special education, using that as sort of a proxy for neurodevelopmental outcomes until 41 weeks, after which point the risk quickly increased again. And the recent Cochrane review called for more research on this topic to be an important thing to consider. I do want to note here that these benefits or these potential benefits are with going past your due date are associated with going past your due date in a single uncomplicated pregnancy. And we cover a lot more in the article, and we’ve really kind of only scratched the surface here. I’m really excited to share this review of the recent research because I know our readers and our professional members are especially so interested in the studies that they can look up and read for themselves. But I think we’re at the end here, Rebecca. And because we’re at the end, I feel like I should ask you, Rebecca, what’s the bottom line?

Dr. Rebecca Dekker – 00:56:14:

So what’s the bottom line about inducing labor for reaching 41 weeks? Well, elective induction at 41 weeks and zero days could help reduce stillbirths and lower the risk of poor health outcomes for babies, especially among first-time mothers. So importantly, we have two large randomized controlled trials published in 2019 that both found benefits to elective induction at 41 weeks instead of continuing to wait for labor until 42 weeks. Both of these trials took place in countries that follow the midwifery model of care and the overall Cesarean rates were low amongst everybody in the study, generally about 10 to 11%. One of these two studies found that there were fewer newborn deaths and stillbirths with 41-week induction. And the other study did not find a difference in deaths, but it found fewer poor health outcomes for babies with 41-week induction as compared to waiting for one more week. If it seems like you’re going past your due date, it’s important to talk with your care provider about the potential benefits and risks of having an elective induction at different time points versus waiting for spontaneous labor for a certain period of time and then perhaps having an induction later if needed. So any conversation about induction should take into account your preferences, your personal birth history, risk factors for stillbirths such as small for gestational age, which is a very important risk factor or it being your first birth, the chances of the induction being successful, including how ripe your cervix is, your hospital’s Cesarean rate with inductions, how well do they do at lowering the Cesarean risk with inductions, and what are some alternatives to the induction? I also think the bottom line includes that non-medical factors are very real when it comes to individual decision making. For example, for some people, the experience of being induced might include potentially more painful contractions leading to being tethered for monitoring and IV fluids more likely to need an epidural or being confined to bed. And those interventions might not make much of a difference to someone who’s already planning to have multiple interventions in their birth, but it could make a big difference to someone who is planning to use movement, freedom of movement, freedom of eating and drinking and other comfort measures with an unmedicated birth. Another example of how individual preferences can come into play is if someone has experienced miscarriages or stillbirth in the past or has important risk factors for stillbirth. They may have a strong preference for elective induction in order to lower the overall risk of stillbirth by any means necessary. And I want to affirm that all these experiences and preferences are valid. So here at EBB, I hope you found this research helpful, all about the evidence on inducing labor for when you go past your due date and reach 41 weeks. We also cover 42 weeks in the article as well as another time point. Just go to ebbirth.com/inducingduedates and you can download a free handout all about the evidence on inducing for 41 weeks. And we have a lot of other resources available. All of the references, you can just click on the link and go straight to the studies that we talk about and resources that we share in there for stillbirth and newborn loss. So thank you, Sara, for your hard work on this article. And I’m excited that we’re getting it into everybody’s hands and their ears today.

Dr. Sara Ailshire – 00:59:41:

Thank you. It’s so much fun to get to talk about this. And I’m so excited for people to read and I hope it is helpful.

Dr. Rebecca Dekker – 00:59:49:

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Over the past 30 years, inductions for non-medical reasons have been on the rise in the U.S. and around the world (Little 2017). Increasingly, more pregnant people are being induced because they are close to, have reached, or have passed their estimated “due date” of 40 weeks.

Here at Evidence Based Birth®, we’ve already covered the evidence on “What is a Due Date?” and “Elective Induction at 39 Weeks.” But what are the benefits and risks of elective induction once you’ve passed your estimated due date? Is there a certain time point when the risks of continuing the pregnancy outweigh the risks of an elective induction? And how might your goals and preferences for birth influence your decision of a) waiting for labor to start or b) going ahead and inducing labor once you’ve reached or passed your due date? These are the questions we will address in this Evidence Based Birth® Signature Article!

Note: In this Signature Article, we will focus on the evidence on induction at 41 weeks and later. Why? Because 41 weeks represents the time point when the distinction between an elective induction and a medically indicated induction begins to blur. So, there is a need for Evidence Based Birth® to help with informed discussions by providing a summary of the evidence on induction at 41 weeks and later.

 

 

Glossary

  • Estimated due date = Traditionally considered to be 40 weeks and 0 days after the last menstrual period.
  • Last menstrual period (LMP) = First day of the last period.
  • Apgar score = A quick test given to newborns to assess their health status (usually done at 1 and 5 minutes after birth).
  • Stillbirth = Death in utero due to any cause after 20 weeks gestation.
  • Neonatal death = Death at <28 days after birth, further delineated into early neonatal (<7 days), and late neonatal (7-27 days).
  • Perinatal death = Includes both stillbirth and neonatal death.
  • Post-dates pregnancy = A common term that means any pregnancy that goes past the estimated 40-week due date; however, it is imprecise and usually replaced with early/full/late/post term:
    • Early-term is between 37 weeks 0 days and 38 weeks 6 days.
    • Full-term is between 39 weeks 0 days and 40 weeks 6 days.
    • Late-term is between 41 weeks 0 days and 41 weeks 6 days.
    • Post-term is 42 weeks and 0 days (294 days total) or later.
  • Medical induction = Starting labor with medical intervention before it begins on its own.
  • Spontaneous labor = A labor starting on its own rather than triggered by medical intervention.
  • Medically indicated induction = An induction for an accepted medical indication from a professional guideline.
  • Elective induction = Induction that is not medically indicated.
  • Expectant management = Waiting for labor to start on its own, usually with fetal and other testing to monitor the mother/baby’s status.
  • Active management = Medical induction for due dates.
  • Absolute risk = the actual, or true, risk of something happening to you as an individual (e.g., a 15% chance of the outcome means it happens to 15 people out of 100).
  • Relative risk = the risk of something happening to you in comparison to someone else (e.g., if your absolute risk is 15% and some else has an absolute risk of 10%, then your relative risk of the outcome is 50% higher than theirs).

How common is it for someone to be induced for going past their estimated “due date?”

In 2022, the total induction rate in the United States was 31.8% (Simpson 2024). But that number may be inaccurate because induction of labor is probably underreported in federal vital statistics (Declercq et al. 2013; NAS 2020). Also, details about induction are not recorded in U.S. birth certificate data. So, we cannot know for sure how often people may have different types of inductions, or why inductions are carried out.

We do know that forty percent (40%) of participants in the 2018 Listening to Mothers in California survey reported that their care provider tried to induce labor (Sakala et al. 2018). The researchers asked mothers to select the reasons that they were induced. Two of the most common reasons for induction included:

  • Out of everyone who was induced, 35% said that they were induced because their baby was full-term and it was close to the due date.
  • Another 22% said that they were induced because the health care provider was concerned that the mother was “overdue.”

What is the difference between a medically indicated induction and an elective induction?

In general, inductions are considered medically indicated when there are medical problems or pregnancy complications present that make it less safe to continue the pregnancy.

Medically indicated inductions refer to inductions where the motivation for attempting to induce labor is either:

  • A response to a medical condition that could threaten the health or wellbeing of the birthing person or fetus.
  • Or, a situation where giving birth could help resolve a medical condition before it becomes worse, such as with pre-eclampsia.

Medically indicated inductions can occur any time during a pregnancy—even before viability, or the age where a fetus can be born and have a chance of surviving outside the womb. In our reference list, see “ACOG 2021” for descriptions of medical conditions in which preterm or early term birth via induction and/or Cesarean may be recommended by providers.

Labor inductions that do not have a clear medical reason (or indication) for taking place are considered elective inductions. Elective inductions might occur for social reasons, such as a pregnant person or health care provider wanting the birth to happen when the preferred provider is available, or to schedule the birth around availability of a partner or support person. They may also occur for other non-medical reasons, such as wanting to be done with an uncomfortable pregnancy, due to distance from a hospital or upcoming weather events, or in order to plan care for other children, pets, or dependents.

In the U.S., elective inductions usually do not occur earlier than 39 weeks and 0 days. This is sometimes called the “39-week rule.”  A set of guidelines jointly published in 2009 by the American College of Obstetricians and Gynecologists (ACOG) ACOG and the Society for Maternal-Fetal Medicine (SMFM) advised against non-medically indicated inductions prior to 39 weeks of pregnancy due to the risk of increased complications for infants born early-term period (between 37 weeks 0 days to 38 weeks 6 days) (ACOG 2019, reaffirmed 2025).

But the distinction between elective versus medically indicated induction is not always clear. Some providers consider induction for late pregnancy (41 weeks 0 days to 41 weeks 6 days) and post-term pregnancy (42 weeks 0 days and later) to be medically indicated because of the increased risks of complications that come with longer pregnancies (Little 2017), while others would still refer to this as an elective induction if there are no health problems existing at that time. To read more about the relationship between risk of complications and length of pregnancy, see the EBB Signature Article on Due Dates here.

When someone gets closer or past their due date, they may face a question of whether to induce labor or wait for labor to start on its own.

  • Elective induction of labor for getting close to, reaching, or passing the due date (without any other health problems indicating a need for induction) is sometimes called active management.
  • Waiting for labor to start on its own, usually with fetal testing to monitor the baby’s status, is called expectant management.

Many researchers have tried to compare the risks and benefits of active management versus expectant management for pregnant people from 39 weeks to 42+ weeks of pregnancy.

Opinions differ on what the best, most inclusive term is for referring to inductions without a medical indication, including when those inductions take place after 40 weeks gestation. In this article we will use the term ‘elective induction’ because it is commonly used in research and writing about this topic for a general audience. We will also make a point to use the terms chosen by researchers when reporting on the evidence to ensure we are accurately representing their findings, even if they differ from our own word choice. Language matters and this categorization of inductions may change at some point. At EBB we will always carefully consider the terms we use and how we apply them and update our usage as needed.

The challenge of choosing the right comparison group to study induction

For many years, the common belief was that elective inductions doubled the Cesarean rate, especially in first-time mothers.

However, in the 2000s and 2010s, some researchers began to dispute the claim that elective induction doubles the risk of Cesarean (Caughey et al. 2006; Einerson & Grobman 2020). They argued that earlier studies—where elective induction showed a doubling in Cesarean rates—were flawed.

In the earlier studies, elective induction was compared only to spontaneous labor: people who were electively induced versus people who went into spontaneous labor. Excluded from these two groups were people who were not electively induced but waited for labor and then ended up having inductions later on, some of which were medically necessary (and, thus, linked to a higher rate of Cesareans). For an example of this earlier flawed research, see this article by Yeast et al. 1999 [https://pubmed.ncbi.nlm.nih.gov/10076139/].

Previous studies compared Cesarean rates of these two groups only:

New researchers pointed out that we need to compare people who have elective inductions with the whole group of those who wait for spontaneous labor—whether or not they actually do have spontaneous labor.

This is a subtle difference, but an important one, because not everyone who waits for labor will actually have a spontaneous labor. Some will develop complications that lead to an induction and increase their risk for Cesarean. The researchers argued that the comparison group must include these people as well.

So, with this new understanding, someone in the wait-for-labor group who ends up being induced later in the pregnancy would not be considered inappropriate crossover between groups. This is because induction later in the pregnancy is a possible outcome with expectant management, just like going into spontaneous labor is a possible outcome.

This graphic shows how you would look at the two groups: the elective induction group versus the entire group of people who were not electively induced at that time—some of whom would, in fact, end up being induced later in the pregnancy.

Since the 2010s, researchers said studies should include all groups:

Because of this flaw in the earlier studies, the researchers argued, those studies don’t give us a true picture of the risks and benefits of elective induction between 39-41 weeks versus waiting for labor to start on its own (“expectant management”).

Elective Induction at 39 Weeks versus Waiting for Labor

In 2018, a study called the ARRIVE trial was published that had a significant impact on induction in American obstetric care. We cover this evidence in depth in our Signature Article: Evidence on the ARRIVE Trial and Elective Induction at 39 Weeks and provide a brief summary below:

Impact of the ARRIVE Trial

The ARRIVE trial (A Randomized Trial of Induction Versus Expectant Management) sought to compare elective induction of labor in the 39th week of pregnancy to expectant management. The ARRIVE researchers hoped their study—a large, randomized, controlled trial—could determine whether elective inductions could lead to a decrease in serious complications or stillbirths for babies. They also wanted to understand if there was a connection between elective induction and an increased risk of Cesarean.

For many years, it was assumed that elective inductions led to higher Cesarean rates. This belief was supported by older studies finding higher Cesarean rates among patients who were induced (Yeast et al. 1999). However, these studies did not have true “elective induction” and “expectant management” groups to compare.

The ARRIVE trial did not find any difference between elective induction and expectant management in terms of death or serious health issues for babies. However, the researchers did find that elective inductions at 39 weeks lowered the risk of Cesarean and pregnancy-related high blood pressure for participants in the study. In our Signature Article ™ Evidence on: The ARRIVE Trial and Elective Induction at 39 Weeks, we dig into this study in detail, describe the limitations of the ARRIVE study, how its publication impacted pregnancy care, and other research on induction at 39 weeks. You can read the evidence on elective induction for 39 weeks here.

Elective Induction at 40 Weeks versus Waiting for Labor

Most of us think of getting induced for due dates as having an induction at 40 weeks of pregnancy. However, there is very little research on inducing on your exact due date or in the 40th week of pregnancy. Instead, most of the research either looks at 39-week inductions or 41–42-week inductions. Few researchers have compared outcomes between elective inductions at 40 weeks vs. waiting until later in pregnancy to be induced. We will point out what these studies found in Table 1.

Elective Induction at 41 Weeks versus Waiting for Labor

In the next section of this article, we review the evidence on induction at 41 weeks versus waiting for labor.

Limits of the Evidence

Before we begin discussing the evidence, it is important to note that there are some major drawbacks to the evidence that we have so far on induction at 41+ weeks versus waiting for labor to start:

  1. Many of the clinical trials were carried out in countries or during time periods with low Cesarean rates. These research findings on Cesarean rates and inductions may not apply to hospitals with high Cesarean rates. If a hospital has a high rate of “failed inductions” and a high rate of Cesareans, this may be due to non-evidence-based restrictions. For example, does your hospital put strict time limits on the length of labor, not allow people in labor to eat or drink at will, or discourage mobility and position changes during labor? If so, then some of this evidence may not apply to you, because induction may be more likely to lead to a Cesarean in your specific hospital!
  2. The correct comparison group for elective induction includes people who are induced later in the pregnancy along with those who go into labor spontaneously. Most researchers only report the results of the two study groups as they were originally assigned (those who were assigned to active management and expectant management), but it can be helpful to look at the results for people who were actually induced or who actually went into spontaneous labor. For example, in the Hannah Post-Term trial (the biggest study about induction for reaching 42 weeks), about one-third of mothers who were assigned to the induction group went into labor spontaneously before the induction. When you look at the breakdown of what actually happened to the people in the two groups (as we do later), it becomes apparent that Cesarean rates are only increased with expectant management when induction occurs later in the pregnancy, and not when mothers go into spontaneous labor.
  3. In most studies, people in the expectant management group had more fetal testing while they were waiting for labor to begin. Some of these tests may have showed possible signs of distress (with some of these results being false positive) (Menticoglou & Hall 2002). Extra fetal testing can possibly lead to higher rates of Cesarean for suspected fetal distress during labor in an expectant management group (Wood et al. 2014). One researcher said, “It may be that the results of our review reflect doctors’ discomfort with delayed delivery in high-risk people that, once they are in labor, manifests as more frequent Cesarean sections: an example of research confirming the biases of the health care community” (Wood et al. 2014: 682). But on the other hand, extra fetal monitoring during expectant management may be protective against stillbirth. We will discuss this more when we get to the SWEPIS trial results later on in this paper.
  4. Induction protocols varied from study to study, and even within studies themselves. In the INDEX trial, methods for cervical ripening and induction varied between providers. This variation in practice means that there’s less certainty about how useful these results are. In the Hannah et al. Post-Term study, people in the active management group first received drugs to ripen the cervix and then drugs to induce labor. Meanwhile, people in the expectant management group who ended up being induced did NOT have cervical ripening. It is known that medical induction without cervical ripening results in higher risk of Cesarean, so in this case, the expectant management group would have been at increased risk of Cesarean compared to the active management group.

Large, Randomized Trials on Induction at 41 Weeks versus Waiting for Labor

Two large randomized, controlled trials on post-term induction came out in 2019. They both found that 41-week induction might improve outcomes for babies.

The INDEX trial from the Netherlands

The trial from the Netherlands is called the INDEX trial, which stands for INDuction at 41 weeks, EXpectant management until 42 weeks (Keulen et al. 2019). It was a multicenter trial, conducted at 123 midwifery practices and 45 hospitals in the Netherlands, where midwives are the lead professionals for most pregnancies and births.

The researchers randomly assigned a total of 1,801 pregnant people to either induction at 41 weeks and 0 to 1 days or to expectant management and induction at 42 weeks and 0 days (if labor had not started on its own by that point). In the Netherlands, labor is not usually induced before 42 weeks with an uncomplicated pregnancy, so they were able to get ethical approval to conduct this study. In the U.S., on the other hand, it is not standard practice to continue expectant management for as long as 42 weeks, so it would have been more difficult to get ethical approval to conduct the study there.

Pregnant people were enrolled into the study between 2012 and 2016. Mothers had to be healthy and pregnant with single, head-down babies. Everyone had to have a gestational age that was estimated with ultrasound before 16 weeks of pregnancy. They excluded anyone with a prior Cesarean, high blood pressure disorders, expected problems with the baby’s growth, abnormal fetal heart rate, or known fetal malformations. Just over half (53.7%) of participants in the study were giving birth for the first time.

In both groups, cervical ripening and induction methods depended on local protocol. This is an important weakness of the study because, like the large Hannah Post-Term trial, individual providers in the INDEX trial may have managed labor inductions differently based on group assignment. The variation in induction methods used in the study also limits the study’s generalizability, or ability to apply the results to the population at large, since care providers lack an induction protocol to replicate.

In the elective induction group, 29% of the participants had spontaneous labor before their induction and 71% were induced. In the expectant management group, 74% of the participants went into labor spontaneously before their planned induction and 26% were induced. Interestingly, the median decrease in length of pregnancy between groups was only two days. In other words, the median pregnancy was only 2 days shorter in the elective induction group, compared to the expectant management group.

There was no protocol for fetal monitoring during expectant management (it varied by local guidelines), but fetal monitoring and assessment of amniotic fluid levels was typically performed between 41-42 weeks.

What did the INDEX trial find?

For mothers:

  • No difference in Cesarean rates (11% in both groups).
  • No difference in a combined measure of bad outcomes for mothers (11%-14% both groups). This outcome, called the maternal composite adverse outcome rate, was a combined outcome that included one or more of the following events: excessive bleeding after birth (≥1000 mL), manual removal of placenta, severe perineal tears, intensive care admission, or maternal death. No maternal deaths occurred in either group. The researchers did not report on uterine rupture.

 For babies:

  • Babies in the elective induction group had a lower composite adverse outcome rate (1.7% versus 3.1%). For babies, this combined outcome included perinatal death, Apgar* score <7 at five minutes, arterial pH <7.05, meconium aspiration syndrome, nerve injury, brain bleeds, or admission to a newborn intensive care unit (NICU). It was mostly the lower rate of Apgar score <7 at five minutes that contributed to the lower combined adverse outcome with the elective induction group (1.2% with elective induction versus 2.6% with expectant management). The authors note that there was no difference in rates of Apgar score of <4 at five minutes; however, the combined outcome was still significantly lower in the elective induction group if using Apgar score <4 at five minutes and excluding fetal malformations (differences of fetal development, sometimes called congenital anomalies).
  • One stillbirth occurred in the elective induction group at 40 weeks and 6 days (before the mother was induced) and two stillbirths occurred in the expectant management group (while the mothers were waiting for labor). One was to a first-time mother at 41 weeks and 3 days; her baby was small for gestational age.The other stillbirth was to an experienced mother at 41 weeks and 4 days; her placenta showed signs of infection. There were no newborn deaths in either group.

*An Apgar score is a standard way to quickly assess the health of a newborn at one minute and again at five minutes after the birth. At five minutes after the birth, a total score of 7-10 is reassuring, 4-6 is moderately abnormal, and 0-3 is low. The Apgar does not predict the risk of death or long-term health outcomes—this has never been a goal of the Apgar score. Instead, it’s used to assess which babies need immediate medical assistance (AAP & ACOG 2015).

Small for gestational age means that a baby is estimated to be at or below the 10th percentile for weight; this does not necessarily mean that anything is automatically wrong. Some healthy babies are just smaller sized than others, which is sometimes referred to as being constitutionally small and healthy (Melamed et al. 2021). However, sometimes a baby being very small means that something has gone wrong. This could be because they have an underlying genetic condition, or there is another problem in pregnancy that could negatively impact their growth. We go into further detail on this topic in the EBB Signature Article on Due Dates.

In summary, the INDEX trial found that elective induction at 41 weeks resulted in similar Cesarean rates and fewer overall bad outcomes for babies compared to waiting for labor until 42 weeks. The absolute risk of a bad outcome (a combined measure of perinatal death, intensive care admission, or Apgar score <4 at five minutes) was low in both groups (1.7% versus 3.1%).

2022 Companion study to the INDEX trial

Not everyone who was asked to participate in the INDEX trial agreed to take part. In fact, 69% of those who were invited to participate in the trial declined, because they did not want to be randomly assigned to one group or another (Bruinsma et al. 2022). In Bruinsma et al. (2022), researchers followed the labor and birth outcomes of those who declined participation in the INDEX trial, in order to see if characteristics and health outcomes differed between those who participated in the trial and those who declined.

This study was conducted in 90 midwifery practices and 12 hospitals in the Netherlands between 2012 and 2016. The researchers recruited 3,642 women who met the same requirements as the women who enrolled in the INDEX trial. For the analysis, participants were sorted into three categories according to their preferences for either 1) induction, 2) expectant management, or 3) unknown preference:

  1. The induction group consisted of women who preferred to be induced at 41 weeks and 0 days at the time they agreed to be in the study. In the days after they joined the study (but before their planned induction), the women could have a spontaneous labor, choose to be induced electively, or be induced medically for a fetal or maternal condition that emerged.
  2. The expectant management group consisted of women who preferred expectant management. After joining the study, women in the expectant management group could have had a spontaneous onset of labor, a medically indicated induction, or an induction for post-term pregnancy ≥ 42 weeks pregnancy.
  3. The unknown preference group consisted of women who did not share a preference for either induction or expectant management, women who preferred induction but had a spontaneous onset of labor after 41 weeks + 1 days, or those who preferred expectant management but had an elective induction of labor at 41 weeks + 2 days to 41 weeks + 6 days

Data were analyzed according to assignment to the induction and expectant management groups only. Because women’s preference and actual management were inconsistent and/or unclear in the unknown preference group, it was not possible for researchers to assign them to an induction or expectant group.

For mothers:

  • Overall, the Cesarean rate was 10.5% in the induction group and 8.9% in the expectant management group. For people giving birth for the first time, the Cesarean rate was also lower in the expectant management group compared to the induction group.
  • The combined measure of poor health outcomes for mothers was similar in both groups: 11.6% in the induction group vs. 11.4% in the expectant group. This study’s maternal composite adverse outcome rate included excessive bleeding after birth (≥1000 mL), and/or manual removal of placenta, and/or severe tears, and/or intensive care admission, and/or maternal death.
  • One maternal death occurred in the expectant management group from an amniotic fluid embolism.
  • Five other women were admitted to the ICU, four from the unknown preference group and one from the expectant management group. Most of the ICU admissions were due to severe postpartum hemorrhage.

An amniotic fluid embolism (AFE) is a rare, life-threatening complication in pregnancy that usually occurs close to or shortly after birth (Carlson & Mikes 2024). An AFE happens when a birthing person has a severe reaction to their bloodstream being exposed to amniotic fluid. It’s common for the bloodstream to be exposed to amniotic fluid, but an amniotic fluid embolism reaction is very rare. So, researchers are still trying to understand why this rare but serious complication occurs in some people but not others.

 For babies:

  • Babies in the elective induction group had a lower composite adverse outcome rate (1.1% versus 1.9%). For babies, this combined outcome included one or more of the following: perinatal death, Apgar score <7 at five minutes, arterial pH <7.05, meconium aspiration syndrome, nerve injury, brain bleeds, or admission to a newborn intensive care unit (NICU).
  • No stillbirths occurred in the study, while one neonatal death occurred the day of birth in the unknown preference group. The infant who died was born to a woman who went into spontaneous labor at 41 weeks and 2 days and experienced sudden excessive blood loss after the spontaneous rupture of membranes. The baby’s heart rate slowed, and an emergency Cesarean was performed. The baby died due to complications of a lack of oxygen (asphyxia) later that day.

So, in summary, this companion study to the INDEX trial found a lower rate of Cesareans for those who chose expectant management. They also observed a similar rate of poor maternal health outcomes with induction versus expectant management. Those who chose an elective induction at 41 weeks had fewer overall adverse events for newborns. However, the absolute risk for adverse newborn outcomes was low in both groups, and it was lower than the rates observed in the original INDEX trial.

The SWEPIS trial from Sweden

The SWEdish Post-term Induction Study (SWEPIS) gained a lot of media attention with headlines like “Post-term pregnancy research cancelled after 6 babies die.” Indeed, the researchers planned to enroll 10,000 mothers from multiple centers across Sweden but ended up stopping the study early (with about 1,380 people in each group) after their Data Safety and Monitoring Board found a significant difference in perinatal death between groups (Wennerholm et al. 2019).

At the time the study was conducted, midwives in Sweden (similar to those in the Netherlands) did not typically induce labor before 42 weeks with uncomplicated pregnancies, and midwives manage most pregnancies and births. The SWEPIS investigators wanted to compare elective induction at 41 weeks and 0 to 2 days versus expectant management and induction at 42 weeks and 0 to 1 day (if still no labor).

From 2015 to 2018, researchers enrolled healthy mothers with single, head-down babies. Gestational age was required to be estimated with a first or second trimester ultrasound. More than half (54.9%) of participants were giving birth for the first time. They excluded anyone with a prior Cesarean, diabetes, low fluid levels, high blood pressure disorders, small-for-gestational-age babies, or known fetal malformations. There is a low stillbirth rate in Sweden, so they planned to enroll 10,000 people, but they ended up not needing nearly that many people to see a difference in perinatal outcomes between groups.

A big strength of the SWEPIS trial is that they defined an induction protocol, and the same protocol was used with the people assigned to elective induction and those assigned to expectant management who were induced for medical reasons or because the mother reached 42 weeks of pregnancy. If the mother’s cervix was already ripe, then they broke her water and gave her synthetic oxytocin as needed. If the mother’s cervix was not ripe or the baby’s head not engaged, they used any of the following: mechanical methods, misoprostol, prostaglandins, and/or synthetic oxytocin after ripening the cervix first.

In the elective induction group, 14% of participants had spontaneous labor before their scheduled induction and 86% were induced. In the expectant management group, 67% of the participants went into labor spontaneously before their planned induction and 33% were induced. Similar to the INDEX trial, the median decrease in length of pregnancy between groups was slim—pregnancy in the elective induction group was, in general, only 3 days shorter.

What did the SWEPIS investigators find?

For babies:

  • The study was stopped early after five stillbirths and one early newborn death occurred in the expectant management group, out of 1,379 participants (4.4 deaths per 1,000). Zero deaths had occurred in the elective induction group, out of 1,381 participants. All five stillbirths in the expectant management group occurred between 41 weeks, 2 days and 41 weeks, 6 days. Three of the stillbirths had no known explanation, one stillbirth occurred with a small for gestational age baby, and the other was with a baby who had a heart defect. The one newborn death occurred four days after birth due to multiple organ failure in baby that was large for gestational age.
  • There was no difference in their composite perinatal outcome (2.2% to 2.4% in both groups). This combined outcome included perinatal death, Apgar score <7 at 5 minutes, pH less than 7, brain bleeds, brain injury from low oxygen, seizures, meconium aspiration syndrome, need for ventilation after birth, or nerve injury. However, there was a significant difference in perinatal death alone.
  • The elective induction group babies were less likely to be admitted to intensive care (4% versus 5.9%), had fewer cases of jaundice (1.2% versus 2.3%), and fewer of them were big babies (4.9% versus 8.3%).

All of the perinatal deaths in the SWEPIS study occurred during first-time births, which suggests that 41-week induction may be especially beneficial at preventing stillbirths and newborn death for first-time mothers. They found that it only took 230 inductions at 41 weeks to prevent one perinatal death. This is a much lower number than previously thought. So why is it that the 41-week induction was protective against stillbirth? Well, the authors hypothesize that when complications are present at the end of pregnancy (e.g., with the placenta, umbilical cord, or fetal growth) these complications may become more significant as the days of pregnancy progress, leading to a higher death rate with expectant management past 41 weeks.

As we mentioned earlier, fetal monitoring in the SWEPIS study was done per local guidelines. In other words, there was no official study protocol for fetal monitoring during the 41st week of pregnancy. The mothers recruited in the Stockholm region (about half the people in the study) had ultrasound measurement of amniotic fluid volume and abdominal diameter at 41 weeks, but these checks were not regularly performed at the other centers. Importantly, none of the six perinatal deaths occurred in the Stockholm region of Sweden, where this type of fetal monitoring was performed. This means that the results of the SWEPIS study may not apply equally to mothers who receive fetal monitoring at the end of pregnancy. Also, since all of the perinatal deaths occurred to first-time mothers, the study results may not apply equally to experienced mothers.

If you recall, the INDEX trial that we covered earlier did not find a significant difference in perinatal death between the induction group and the expectant management group. This could be because INDEX was a smaller study and not able to detect differences in rare outcomes like death. It could also be that there was better fetal monitoring of participants between 41 and 42 weeks in the INDEX trial, leading to fewer perinatal deaths. We can’t be certain, because there were no published fetal monitoring protocols in either trial. Finally, the participants in the INDEX expectant management group tended to give birth a little sooner than the participants in the SWEPIS expectant management group, and that might help to explain the higher perinatal death rate in SWEPIS.

For mothers:

  • There was no meaningful difference in Cesarean rates (10-11% in both groups).
  • More mothers in the elective induction group had inflammation of the inner lining of the uterus usually due to infection, called endometritis (1.3% versus 0.4%).
  • More mothers in the expectant management group developed high blood pressure disorders at the end of pregnancy (3% versus 1.4%).
  • There were no cases of uterine rupture in either group.
  • Qualitative data found that people in the expectant management group struggled with negative thoughts, and they described feeling in “limbo” while they waited for either labor or a 42-week induction.

Research on Induction in Sweden after SWEPIS

Researchers credit the public controversy around the SWEPIS study as igniting the public debate around when to induce labor at the end of pregnancy (Källén et al. 2025). In 2021, Swedish national guidelines about the management of late-term pregnancies changed to recommend that all women should be offered an induction at 41 weeks or an individual plan aiming at birth or inducing labor by 42 weeks (Källén et al. 2025; Raoust et al. 2024).

In Källén et al. (2025), researchers wanted to compare maternal and perinatal outcomes before and after the 2021 change towards more active management of late-term pregnancies in Sweden. To do so, they reviewed the medical records of 150,370 women with single, head-down babies who gave birth between January 2017 to December 2019 (before the change in guidelines) and January 2020 to October 2023 (after the change in guidelines).

This is the numerical breakdown of women in the study:

  • January 2017 to December 2019 (pre-SWEPIS)
    • 41 weeks 0 days or later: 71,565 participants
    • 39 weeks 0 days to 40 weeks 6 days: 160,487 participants
  • January 2020 to October 2023 (post-SWEPIS)
    • 41 weeks 0 days or later: 78,805 participants
    • 39 weeks 0 days to 40 weeks 6 days: 198,061 participants

The primary outcomes that researchers looked at were stillbirth and neonatal death within 28 days of birth, composite adverse newborn outcomes (including death, Apgar score < 4 at five minutes, brain injury from low oxygen, meconium aspiration syndrome, birth trauma) with or without admission to the neonatal intensive care unit for 4 days or longer, and emergency cesarean rates. The researchers also looked at negative perinatal and neonatal outcomes listed above considered individually rather than as a group, as well as vacuum extraction or forceps assisted birth, severe perineal tears, postpartum hemorrhage, and endometritis. They also asked questions about the experience of childbirth before being discharged from the hospital and two months after birth.

Note: The researchers reported their findings both in terms of absolute risk, the actual risk of something occurring, as well as relative risk, or the risk of something happening relative to something else. For an in-depth explanation of absolute versus relative risk, see the EBB Signature Article on Due Dates here.

For babies:

  • The absolute risk of stillbirth and neonatal death within 28 days of birth for those babies born at or beyond 41 weeks decreased from 1.7 per 1,000 infants (0.17%) pre-SWEPIS to 0.9 per 1000 infants post-SWEPIS (0.09%), a relative reduction of about half (47%).
  • There was also a reduction in the relative risk of stillbirth and neonatal death for babies born between 39 weeks 0 days to 40 weeks 6 days between of 14%.
  • Infants born post-SWEPIS had significantly lower risk of birth trauma (12.2 cases per 1,000 versus 14.9 per 1,000, or 1.22% versus 1.49%) and a significantly lower risk of composite adverse outcomes (50.5 per 1,000 versus 53.9 per 1,000 or 5.05% versus 5.39%).

For mothers: 

  • The researchers found that induction rates among pregnancies that went beyond 41 weeks and 0 days increased from 33.7% pre-SWEPIS to 52.4% post-SWEPIS.
  • Emergency Cesareans at or beyond 41 weeks increased, from 10.5% pre-SWEPIS to 11.9% post-SWEPIS, a relative increase of 8%. The use of forceps or vacuum to assist in birth also increased, from 7.8% of births to 8.3% of births. The rate of vaginal non-instrumental births decreased, from 81.6% to 79.8%.
  • The relative risk of emergency Cesarean also increased 14% among those who gave birth between 39 weeks 0 days and 40 weeks 6 days from pre-SWEPIS to post-SWEPIS.
  • The rate of severe perineal significantly decreased from 3.7% pre-SWEPIS down to 3.5% post-SWEPIS.
  • The rate of postpartum hemorrhage increased from 9.2% pre-SWEPIS to 10.1% post-SWEPIS.
  • Women’s experiences of childbirth were slightly better post-SWEPIS, with 6.5% of birthing people reporting a negative childbirth experience post-SWEPIS compared to 7.3% pre-SWEPIS.

In summary, the researchers found that the change in guidelines post-SWEPIS was associated with reduced stillbirths and neonatal deaths and improvement in women’s self-reported experiences in childbirth. When the researchers looked at the rates of inductions across various hospitals where the births in this study took place, they found that hospitals that had a higher induction rate had fewer stillbirths and neonatal deaths compared to hospitals with lower rates of induction. Something that was of concern however were the increased complications for those who had given birth, specifically the increased rate of Cesarean births.

The researchers note that COVID-19 could have affected their results, as changes to medical systems and impacts on health could have played a role in making Cesarean births more likely than they may have been otherwise. Finally, the researchers note that the optimal time to give birth varies according to individual health situations, something that this type of national-level medical records study did not explore.

Small Randomized Trial in Finland

A 2024 randomized control trial in Finland (Place et al. 2024) compared outcomes between women induced at 41 weeks 0 days with women assigned to expectant management and labor induction at 41 weeks 5 days to 42 weeks 1 day of pregnancy. This study was particularly focused on studying the health outcomes of induction and expectant management among those with unripe cervixes. An unripe cervix was defined as a Bishop score of less than 6.

The Bishop score that helps to determine if you are a good candidate for induction is based on five factors:

  1. How dilated (or open) is your cervix?
  2. How effaced (or thin) is your cervix?
  3. How soft is your cervix?
  4. How is your cervix positioned?
  5. How far down the birth canal is your baby’s head?

From 2018 to 2022, researchers enrolled healthy mothers pregnant for the first time with single, head-down babies at all five university hospitals and the largest central hospital in Finland. Gestational age had to be estimated with a 1st trimester ultrasound (performed between 11-13 weeks). They excluded anyone with high blood pressure disorders, uterine scars, small-for-gestational-age or very large-for-gestational age babies, chronic health conditions like HIV or Hepatitis B and C, suspected vaginal or uterine infections, or known fetal or placental malformations.

Participants were randomly assigned to either be induced at 41 weeks 0 days (186 participants) or to expectant management and labor induction at 41 weeks 5 days to 42 weeks 1 day (195 participants). The researchers were primarily interested in the Cesarean rate and composite adverse neonatal outcomes. Their composite adverse neonatal outcome included Apgar score <7 at five minutes, abnormalities in the pH level of the arterial cord blood, and neonatal intensive care unit admission. They also looked at rates of postpartum hemorrhage, manual removal of a retained placenta, severe perineal tears, and maternal infection during or after labor.

Rates of Cesarean and adverse neonatal outcomes were not statistically different between groups, meaning that the researchers could not rule out if any observed differences were due to random chance. The Cesarean rates ranged from 17% to 24%, and adverse neonatal outcomes ranged from 10% to 14%.

Researchers noted that if an early induction (at 41 weeks) had been offered to all of the participants, one case of eclampsia could have been avoided. A participant was screened for symptoms of pre-eclampsia at her initial 41-week 0-day visit and developed eclampsia (a life-threatening seizure complication) at 41 weeks 2 days at home.

Limitations of this study include the low number of people enrolled and the limited data on exact Bishop scores at the 41-week 0-day visit. Recruitment for the study was negatively impacted by COVID-19 and the researchers did not reach their goal of recruiting 400 participants. The researchers also noted that their sample size would have needed to be at least 1042 to be certain that their results could be generalizable, meaning applicable to the general population rather than only their participants. They also noted that their recruitment for the study might have over-selected for active, knowledgeable people as participation required potential participants to reach out to the study team.

Benefits and Risks of Induction at 41 Weeks

Table 2: Induction at 41 Weeks versus Continuing to Wait for Labor up until 42 Weeks

Pros Cons
  • Lower risk of stillbirth, especially among those with risk factors for stillbirth such as being pregnant with your first baby. The absolute risk of stillbirth is (Muglu et al. 2019):
    • 4 out of 10,000 pregnancies at 39 weeks.
    • 7 out of 10,000 pregnancies at 40 weeks.
    • 17 out of 10,000 pregnancies at 41 weeks.
    • 32 out of 10,000 pregnancies at 42 weeks.
  • Lower risk of baby receiving intensive care unit admission.
  • Lower risk of baby having jaundice.
  • Lower risk of having a big baby.
  • Lower risk of Cesarean, may depend on practice setting.
  • Lower risk of a mother developing a high blood pressure disorder at the end of pregnancy.
  • Cognitive benefits for babies during a continued pregnancy appear to increase until 40-41 weeks of pregnancy.
  • Convenience, the ability to end an uncomfortable pregnancy.
    • Potential for medicalization of birth because of the induction (e.g., continuous fetal monitoring).
    • Potential for failed induction leading to a Cesarean.
    • Potential uterine tachysystole (more than 5 contractions in 10 minutes, averaged over a 30-minute window).
    • Potential increase in risk of uterine rupture with medical induction, especially among people with a previous Cesarean.
    • Do not experience all the hormonal benefits of spontaneous labor.
    • Increased risk of mother getting inflammation of the inner lining of the uterus (endometritis).
    • Medically induced contractions may increase pain and make epidural use more likely.

    Elective Induction at around 41 Weeks 4 Days versus Waiting for Labor

    Once a pregnancy continues into the second half of the 41st week or 42 weeks (post-term) and later, most health care organizations recommend induction in order to prevent potential complications. Historically, the most important evidence for this recommendation comes from the Hannah et al. “Post-Term” study.

    The Hannah “Post-Term” study

    Before INDEX and SWEPIS were published, one of the most impactful studies that was done on inducing for passing your due date was the Hannah et al. 1992 Post-Term study. This study was published in the New England Journal of Medicine.

    Between the years of 1985 to 1990, a group of researchers enrolled 3,407 low-risk pregnant women from six different hospitals in Canada into the Hannah Post-Term study. Participants were included if they had a live, single fetus, and were excluded if they were already 3 or more centimeters dilated, had a previous Cesarean, had pre-labor rupture of membranes, or had a medical reason for induction. Unlike the INDEX and SWEPIS trials that induced everyone who had not given birth by 42 weeks and 0 to 1 days, the people assigned to expectant management in the Hannah Post-Term study could be monitored as long as 44 weeks. The study took place in the six Canadian hospitals between the years 1985 and 1990.

    At around 41 weeks, participants were randomly assigned to either to be induced within the next 4 days or to continue their pregnancy with fetal monitoring (expectant management).

    In the induction group:

    • Labor was induced within four days of entering the study (usually about 4 days after 41 weeks).
    • If the cervix was not ripe (< 3 cm dilated and <50% effaced), and if the fetal heart rate was normal, participants were given prostaglandin E2 gel to ripen the cervix.
    • A maximum of 3 doses of gel were given every 6 hours. If this did not induce labor or if the gel was not used, participants were given IV oxytocin, had their waters broken, or both. They could not receive oxytocin until at least 12 hours after the last prostaglandin gel dose.

    In the monitored (expectant management) group:

    • Participants were taught how to do kick counts every day and had nonstress tests 3 times per week.
    • The amniotic fluid level was checked by ultrasound 2-3 times per week.
    • Labor was induced if the nonstress test was nonreactive or showed decelerations, if there was low amniotic fluid (deepest pocket <3 cm), if complications developed, or if the mother did not go into labor on her own by 44 weeks.
    • If doctors decided that the baby needed to be born, mothers did not receive cervical ripening—instead, they either had their water broken and/or IV oxytocin, or they had a Cesarean without labor.

    What did researchers find in the Hannah Post-Term study?

    In the induction group, 66% of people were induced, and 34% went into labor on their own before the induction. In the monitoring group, 33% were induced and 67% went into labor on their own.

    There were two stillbirths in the group assigned to wait for labor, and there were zero stillbirths in the group assigned to induction. However, this difference was not statistically significant. This means that we can’t be sure if it happened by chance or was a true difference between groups.

    The findings on Cesarean rates differ depending on which set of numbers you compare.

    You can look at the outcomes for the two original groups—the people randomly assigned to induction and those assigned to fetal monitoring—or you can look at the breakdown of what actually happened to the people in the two groups. In other words, what happened to the people who were actually induced or actually went into spontaneous labor?

    What happened in the original, randomly assigned groups?

    If you look at what happened in the two original groups (random assignment to elective induction and expectant management groups), the overall Cesarean rate was lower in the elective induction group (21.2% versus 24.5%), even after taking into account whether this was the mother’s first baby, her age, and cervical dilation at the time of study entry.

    There was also a lower rate of Cesareans for fetal distress in the elective induction group versus the expectant management group (5.7% versus 8.3%).

    But what happened to people who were actually induced or actually went into labor on their own?

    If instead of considering the results according to how participants were assigned—to the elective induction and or expectant management groups—you look at what actually happened to the people who were induced or who actually went into spontaneous labor, this is what you will see (Hannah et al. 1992):

    So, we see two very interesting things here: people who went into spontaneous labor, regardless of which group they were originally assigned, had a Cesarean rate of only 25.7%. But if people in the expectant management group had an induction, their Cesarean rate was much higher than all of the other groups—42%!

    The same pattern holds true when you look at experienced mothers (people who had given birth before):

    So, what do these numbers mean?

    Important details from the Hannah Post-Term study are hidden when you only look at the results according to random group assignment. The reported main findings were that a policy of fetal monitoring and expectant management increases the Cesarean rate.

    But a closer look at the findings reveals that only the people who were expectantly managed but then had an induction later in the pregnancy had a really high Cesarean rate. People who were expectantly managed and went into labor spontaneously did NOT have higher Cesarean rates.

    One possible explanation for the high Cesarean rate seen in the people who were assigned to expectant management and then ended up getting an induction is that the people in this group may have been at higher risk for Cesarean to begin with, since a medical complication could have led to the induction. The people who were assigned to expectant management and never developed a complication requiring induction were the lower risk people, the ones less likely to give birth by Cesarean.

    Another factor that could have contributed to the high Cesarean rate in this group is the issue that we discussed previously—that doctors might have been quicker to call for a Cesarean when assisting the labors of people with medical inductions who had longer pregnancies.

    So, if someone is considering expectant management after 41 weeks, one of the benefits is that if they go into labor on their own, they will have a relatively low risk of Cesarean. But one of the risks is that longer pregnancies mean more opportunities for potential complications to show up and if an induction becomes necessary, the risk of a Cesarean with that induction is nearly doubled, from 25.7% to 42%.

    Combining all the Research on Inducing for Various Gestational Ages

    Some researchers have combined data from studies looking at induction at various time points versus expectant management. In this section, we summarize the findings from the 2020 Cochrane Review on this subject, plus provide a table of recent publications that includes both observational studies on this subject and a summary of findings from systematic reviews.

    2020 Cochrane meta-analysis on elective induction versus waiting for labor

    In a 2020 Cochrane review and meta-analysis, researchers compared people who were electively induced to those who waited for labor to start on its own (Middleton et al. 2020). They included 34 randomized, controlled trials (including over 21,000 mothers and infants) comparing a policy of induction at or beyond term versus expectant management. The trials took place in Austria, Canada, China, India, Finland, Malaysia, Netherlands, Norway, Russia, Spain, Sweden, Thailand, Tunisia, Turkey, the U.K., and the U.S.

    Most of the data (about 59%) came from trials of elective induction that took place at 41 weeks or later. The Hannah Post-Term trial, which we described in the previous section, was the largest trial included.

    What did they find?

    A policy of induction was linked to 69% fewer perinatal deaths compared to expectant management (4 deaths versus 25). Different studies took different approaches to what deaths they included based on the ultimate cause. The Hannah Post-Term trial excluded deaths due to fetal malformations, but some of the smaller trials did not. Deaths from the SWEPIS study included a baby with a heart defect not considered to be fatal, and so this stillbirth was included by the researchers. If we exclude the three deaths from severe fetal malformations, then there were 3 deaths in the induction group and 22 deaths in the expectant management group. Overall, the number needed to treat was 544 inductions to prevent 1 perinatal death. Specifically, there were fewer stillbirths with a policy of induction (2 stillbirth versus 16). The absolute risk of perinatal death was 3 deaths per 1,000 births with a policy of expectant management versus 0.4 deaths per 1,000 births with a policy of induction.

    A policy of induction was also linked to fewer Cesareans compared to expectant management (16.7% versus 18.6%).

    Fewer babies assigned to induction had Apgar scores <7 at five minutes compared to those assigned to expectant management (1% versus 1.3%). There were little to no differences between groups in the rate of forceps/vacuum birth, perineal trauma, excessive bleeding after birth, duration of labor, initiation of breastfeeding.

    As in previous versions of this Cochrane review, Middleton et al. (2020) were not able to find differences between timing of induction (less than 40 weeks versus 40-41 weeks versus ≥41 weeks) or by the state of the cervix for perinatal death, stillbirth, or Cesarean. The authors concluded that individualized counseling might help pregnant people choose between elective induction at or beyond 41 weeks or continuing to wait for labor, and that providers must honor their values and preferences. We need more research to know who would or would not benefit from elective induction and the optimal time for induction is still not clear from the research.

    Table 1: Research on Elective Induction for Various Gestational Ages

     

    Study

    Study Type

    Description

    Major Findings

    Reviews and Meta-Analyses

    Alkmark et al. 2020 ·   Meta-analysis

    ·   Analyzed data from 3 randomized trials totaling 5,161 participants to compare outcomes between induction of labor at 41 weeks or expectant management until 42 weeks.

    ·   Trials reviewed included the two major 2019 trials (INDEX, SWEPIS), and a 2005 Turkish study (Gelisen et al. 2005).

    ·      Overall, induction at 41 weeks reduced the composite perinatal outcome of stillbirth and infant death or severe newborn complications (0.4% vs. 1%), and stillbirth and infant death alone (0.04% vs 0.35%), without increasing the risk of Cesarean birth, forceps- or vacuum-assisted vaginal birth, severe perineal tears, or postpartum hemorrhage.

    ·      Sub-group analysis showed that the risk of composite perinatal outcome in the induction group was significantly decreased for those giving birth for the first time compared to expectant management (0.3% vs. 1.6%), but not for those who had given birth before.

    ·      Overall, induction at 41 weeks improved infant outcomes compared with expectant management until 42 weeks without increasing the Cesarean rate.

     

    Geneen et al. 2022 ·   Systematic review and meta-analysis

    ·   Reviewed 20 randomized controlled trials published between 1975 and 2021with a total of 15,725 participants.

    ·   Compared results for induction versus expectant management both week to week as well as overall.

    ·      When comparing induction at 41 weeks to waiting until 42 weeks (5 RCTs, 5,819 participants) there were fewer stillbirths and infant deaths and neonatal intensive care unit admissions in the 41 week induction group (rated as low-to-moderate quality evidence).

    ·      When investigating other week to week comparisons (40 week induction versus expectant management to 42 weeks; 39 week induction versus 42 weeks; 39 week induction versus 41 weeks; and 41/42 week induction versus 43/44 weeks) there was no evidence of a benefit, but researchers note there is a need for more data on week-to-week comparisons, as very little exists.

    Jeer et al. 2023 ·   Systematic review and meta-analysis

    ·   Reviewed 44 studies published between 1969 and 2021 with over 46,000 participants (23,960 women and 22,191 babies).

    ·   Aimed to describe the ideal gestational age (after 37 weeks) to offer an induction of labor in uncomplicated pregnancies that can result in the best maternal and newborn outcomes.

    ·   Compared the odds of adverse maternal and perinatal complications for planned induction versus expectant management, both overall and week to week.

    ·      The odds of perinatal death, stillbirth, and admission to NICU were reduced overall in the induction group compared to the expectant management group.

    ·      The odds of Cesarean birth were reduced in the induction group compared to the expectant management group.

    ·      The odds of Cesarean were reduced with induction of labor at 39 weeks compared to induction at or after 40 weeks.

    ·      The odds of admission to NICU were lower with induction of labor at 41 weeks compared to induction at or after 42 weeks.

    ·      There were no significant differences for any other outcomes with week-to-week comparisons of induction of labor versus expectant management for an additional week or longer (induction at ≤38 weeks versus induction at ≥ 39 weeks; induction at 39 weeks versus induction at ≥ 40 weeks; induction at 40 weeks versus induction at ≥ 41 weeks; induction at 41 weeks versus induction at ≥ 42 weeks; and induction at 42 weeks versus induction at ≥ 43 weeks).

    Observational Studies

    Andersson et al. 2022 ·   Study of national birth records in Denmark.

    ·   Compared the risk of poor newborn outcomes and pregnancy- and birth-related complications between gestational age 41 weeks 0 days to 41 weeks 3 days (“early” group) as compared to 41 weeks 4 days and 42 weeks 0 days (“late” group).

    ·   Included all single babies (no multiples) in headfirst position without major congenital malformations, with confirmed gestational age, and with intended vaginal delivery in Denmark between the years 2009 and 2018.

    ·   The total number of births in the study was 134,877. Of these, 79,160 births occurred between 41 weeks 0 days and 41 weeks 3 days, and 55,717 births occurred between 41 weeks 4 days to 42 weeks 0 days.

     

    ·      The risk of low Apgar score at 1 minute after birth was increased in the late group. The risk of a 0-3 Apgar score increased from 1% to 1.3%. The risk of a 4-6 Apgar score increased from 3% to 3.7%. The risk of Apgar score below 7 after 5 min increased from 0.6% to 0.7% between groups.

    ·      In the late group, the percentage of infants with meconium aspiration syndrome increased from 4.4% to 5.4%.

    ·      More infants in the late group needed breathing support (4.7% vs 4.2%), mechanical ventilation (2.0% vs 1.4%) and hypothermia treatment (0.9% vs 0.7%).

    ·      The risk of stillbirth was very low, and researchers did not find an increased risk in the late group compared to the early group.

    ·      The risk of newborn death (within 28 days of birth) was 0.3% in the early group and 0.4% in the late group.

    ·      The risk of a combined outcome of newborn death or admission to the NICU was higher in the late group (2.7% vs. 1.9%).

    ·      The risk of low birth weight (below 10th percentile) was higher in the late group compared to the early group, even after adjusting for other factors (11.5% versus 10.4%). The risk of high birth weight (above the 90th percentile) was lower in the late group (7.1% vs 7.9%).

    ·      The risk of severe perineal tears involving the anal sphincter muscle was 3.5% in the early group and 4.1% in the late group.

    ·      The risk of postpartum hemorrhage increased in the late group.

    ·      Researchers also detected an overall increase of risk in other birth complications in the late group, including shoulder dystocia, emergency Cesarean, maternal fever, and operative vaginal birth.

    ·      Researchers concluded that this information could guide more specific recommendations about when to recommend induction after 41 weeks.

    Bengtsson et al. 2023 ·   Study of national birth records in Sweden.

    ·   Compared newborn outcomes between elective induction and expectant management.

    ·   Included all single babies (no multiples) in headfirst position without major congenital malformations, confirmed gestational age between 37 weeks 0 days and 41 weeks 6 days, and with intended vaginal delivery in public hospitals in Sweden between the years 1999 and 2017.

    ·   The total number of births in the study was 1,361,764. Most births (1,269,951) had a spontaneous onset of labor, while 91,813 were elective inductions.

    ·      Over the study period, the rate of elective inductions more than doubled from 7.2% in 1999 to 16.4% in 2017.

    ·       Elective induction at 37–38 weeks was associated with an increased odds for chorioamnionitis (infection of the placenta and amniotic fluid), bacterial neonatal sepsis (newborn infection of the bloodstream), intracranial hemorrhage (newborn brain bleed), hypoxic ischemic encephalopathy (brain injury due to lack of oxygen), Apgar score of <7 at 5 minutes, and assisted ventilation, when compared to deliveries with spontaneous labor onset. The highest increases in risk were found for chorioamnionitis and intracranial hemorrhage.

    ·      Elective induction at 39–41 weeks was associated with an increased risk of chorioamnionitis, intracranial hemorrhage, hyperbilirubinemia (newborn jaundice), Apgar score of <7 at 5 minutes, newborn seizures, and assisted ventilation, compared to deliveries with spontaneous labor onset. The highest increased risk was found for chorioamnionitis.

    ·      The researchers concluded that inductions were associated with an increase in risk for some newborn complications, but the researchers could not determine what the ultimate cause of these increased risks were. They advised that inductions could come with risks, and that providers should advise patients of the potential for certain increased risks with induction.

    Dahlen et al. 2021 ·   Study of state birth records in Wales.

    ·   Compared interventions and outcomes for mothers and babies between induction and spontaneous onset of labor. They also looked at long-term health outcomes for the children born in this study, up to 16 years of age.

    ·   Study included all single babies (no multiples) in headfirst position without major congenital malformations, and a confirmed gestational age between 37 weeks 0 days and 41 weeks 6 days. All women included in the study were between 20 and 35 years of age. People with health complications, who had elective Cesareans, or inductions for medical reasons were excluded from the study. All participants were drawn from birth records from New South Wales between 2001 and 2016.

    ·   The total number of births in the study was 474,652. Most births (405,255) were a result of spontaneous labor, the remaining births (69,397) were elective inductions.

    ·      People who gave birth for the first time with induction had lower rates of spontaneous vaginal birth (42.7% vs 62.3%), as well as higher rates of forceps- or vacuum-assisted birth (28.0% vs 23.9%%), Cesarean (29.3% vs 13.8%), epidural (71.0% vs 41.3%), episiotomy (41.2% vs 30.5%) and postpartum hemorrhage (2.4% vs 1.5%).

    ·      People who were not giving birth for the first time who had an induction had a lower rate of Cesarean compared to the spontaneous labor group (5.3% vs 6.2%).

    ·      People giving birth for the first time (4.2% vs 4.9%) and those who had given birth previously (0.7% vs 1.2%), in the induction group had a lower rate of severe perineal tears than the spontaneous labor group.

    ·      Between induction and spontaneous birth groups, there were no major differences in infant and child outcomes including hospitalization for asthma or eczema, or newborn death (rates ranged from 0.06% to 0.08%), or in total deaths up to 16 years of age.

    ·      Following inductions at 40 and 41 weeks, there was a significantly lower rate of third- and fourth-degree tears compared to induction earlier or later.

    ·      Researchers concluded that in this study induction of labor for non-medical reasons was associated with higher rates of birth interventions, especially during first-time births. They also found that gestational age made an impact, and that rates of short-term negative outcomes in babies were higher in those born between 37 and 38 weeks and lower in the group born after 39 weeks.

    Haavaldsen et al. 2022 ·   Study of national birth records in Norway.

    ·   Examined whether a national increase in inductions was associated with changes in pregnancy outcomes.

    ·   Included all single babies (no multiples) born between 37 weeks 0 days and 42 weeks 6 days in Norway between the years 1999 to 2019.

    ·   The total number of births in the study was 1,127,945.

    ·      In Norway the rate of labor induction increased from 9.7% to 25.9% between 1999 and 2019. The increase in inductions was highest at 41 weeks, rising from 7.5% in 1999 to 28.6% in 2019. The proportion of births that occurred during the 42nd week decreased from 8.9% of all births in Norway to 4.7% during the same period.

    ·      During the study period, a small decline in fetal deaths was observed in all gestational weeks, except week 41. The overall decline was from 0.18% in 1999–­ 2004 to 0.13% during 2015–­ 2019.

    ·      There were no overall changes in other perinatal outcomes including Apgar score < 7 at 5 minutes, admission to NICU, or newborn death.

    ·      The rate of postpartum hemorrhage increased from 11.4% in 1999 to 30.1% in 2019. The prevalence of urgent Cesareans increased from 6.5% to 9.3%, and vacuum- and/or forceps-assisted deliveries increased from 7.8% to 10.4%.

    ·      The researchers concluded that the increase in labor inductions was accompanied by a small decline in fetal deaths, but no decline in other negative newborn outcomes. They hypothesize that in settings where the rate of negative newborn outcomes is already low, the benefits of increased inductions may not outweigh the side effects or the costs.

    Ravelli et al. 2023 ·   Study of national birth records in the Netherlands.

    ·   Study compared perinatal outcomes in low-risk pregnancies between induction at 41 weeks and expectant management.

    ·   Study included all single babies (no multiples) in headfirst position without major congenital malformations, and a known gestational age between 41 weeks 0 days and 42 weeks 0 days weeks born in the Netherlands between the years 2010 to 2019.

    ·   The total number of births in the study was 239,971. Participants in the study were further divided into three groups:

    ·   G1: Induction at 41 weeks and 0 to 1 day compared with expectant management from 41 weeks 0 days up to 42 weeks 0 days.

    ·   G2: Induction at 41 weeks and 2 to 3 days compared with expectant management 41 weeks 0 days up to 42 weeks 0 days.

    ·   G3: Induction at 41 weeks and 4 to 5 days compared with expectant management from 41 weeks 0 days up to 42 weeks 0 days.

    ·      Compared with expectant management from 41 weeks 0 days up to 42 weeks 0 days, induction at 41 weeks and 0 to 1 day decreased the rate of stillbirths in people giving birth for the first time and for those who had given birth previously.

    ·      For people giving birth for the first time, all of the induction groups had higher rates of low Apgar scores and NICU admissions.

    ·      Inductions across all groups were associated with a higher Cesarean rate.

    ·      Authors recommend shared decision making for induction at 41 weeks rather than a blanket policy of inducing everyone at 41 weeks.

     

    Frequently Asked Questions

    Q: Has the question about the ideal time for induction been settled?

    A: After 41 weeks, concerns begin to grow about the potential for increased risk for stillbirth, as well as the increased risk of poor outcomes for the birthing person or baby. Most guidelines will recommend that someone who has not gone into labor on their own by 42 weeks should be induced. However, neither these concerns nor the existing guidelines have created a hard and fast rule about when a person should be induced to have the best possible chance of avoiding potentially negative outcomes while also maximizing the benefits of carrying a pregnancy to term and allowing the body to begin labor on its own without induction.

    The authors of a systematic review from 2019 raise concerns that routine induction prior to post-term puts a large number of pregnant people at risk of harmful side effects from induction (Rydahl et al. 2019a). This review came out too early to include the SWEPIS and INDEX trials.

    Unlike the Middleton et al. (2020) Cochrane review, Rydahl et al. applied stricter criteria to the studies they included. They restricted studies to only those published within the last 20 years, with low-risk participants, and compared routine induction at 41 weeks and 0 to 6 days versus routine induction at 42 weeks and 0 to 6 days. Altogether, they included three observational studies, two randomized controlled trials (RCTs), and two “quasi-experimental” studies (which means they compare groups in a way that isn’t truly random).

    Combining the two RCTs with the two quasi-experimental studies, there was one perinatal death in the 41-week induction group and six deaths in the 42-week induction group (a perinatal death rate of 0.4 versus 2.4 per 1,000). The finding was not statistically significant. These same studies showed no difference in Cesarean rates between groups; however, the authors did report that one observational study found an increase in the Cesarean rate with the 41-week induction group.

    Back in 2011, Denmark changed its national policy from recommending induction at 42 weeks 0 days, to 41 weeks 3 to 5 days. A recently published study compared birth outcomes before the change in policy (2000-2010) versus after the change (2012-2016) (Rydahl et al. 2019b). The study looked back at all births in Denmark between 41 weeks 3 days and 45 weeks 0 days of pregnancy. Over 150,000 births were included in the dataset.

    They did not find any difference in stillbirths, perinatal death, or low Apgar scores comparing the period before versus after the policy change. Perinatal death was already declining before the policy change in 2011, and it continued the downward trend without an additional impact from the 2011 policy change. There was also no impact on the rate of Cesareans or the use of forceps/vacuum.

    After the policy change in 2011, however, they did see a significant increase in labor inductions and uterine ruptures. During 2011, the rate of people induced at 41 weeks 3 days jumped from 41% to 65%, and the rate of uterine rupture went from 2.6 to 4.2 cases per 1,000. Most of these uterine ruptures (73%) occurred among mothers with a previous Cesarean. Unfortunately, we can’t tell from this study whether the uterine ruptures are occurring among people with a prior Cesarean who are being induced—only that the rate of uterine rupture increased after the policy change, and that most occurred among mothers with a previous Cesarean.

    The researchers expressed concern about the increase in harm without evidence of benefits from a policy of earlier induction. Why did the intervention fail to lower perinatal deaths in Denmark? It could be that the rate was already low in Denmark (and on a downward trend) so there was little opportunity to prevent additional deaths. It could also be that waiting until 41 weeks, 3 days to induce was a few days too late to make a difference. The SWEPIS and INDEX trials found that even a few days after 41 weeks made a significant difference in birth outcomes.

    Q: What about people who are planning a VBAC?

    A: Many people who are planning a vaginal birth after Cesarean (VBAC) are told they must go into labor by 39, 40, or 41 weeks or they will be required to have a repeat Cesarean or induction.

    Research has shown that only about 10% of people who reach term will spontaneously give birth by 39 weeks (Smith 2001; Jukic et al. 2013). So, if a hospital or physician mandates repeat Cesareans for people who have not gone into labor by 39 weeks, this means that 90% of people planning a VBAC with that hospital or physician will be disqualified from having a spontaneous VBAC. Also, some hospitals and providers will not provide inductions with VBACs, which means some people who reach the required deadline will only have one option– repeat Cesarean.

    There is actually no evidence supporting hard-stop “must-give-birth-by-39-weeks” or “give-birth-by-4o-weeks” rules for people planning a VBAC.

    In 2015, researchers looked at 12,676 people who were electively induced at 39 weeks for a VBAC or had expectant management for a VBAC (Palatnik & Grobman 2015).

    Elective induction at 39 weeks was associated with a higher chance of VBAC compared to expectant management (73.8% versus 60-62%), but there was also a higher rate of uterine rupture in the elective induction group (1.4% versus 0.4-0.6%).

    For people who chose not to be induced, the risk of uterine rupture was fairly steady at 39 weeks (0.5% uterine rupture rate), to 40 weeks (0.6%), to 41 weeks (0.4%).

    The first large meta-analysis to specifically look at the link between weeks of pregnancy and likelihood of VBAC was published in 2019 (Wu et al. 2019). It included 94 observational studies with nearly 240,000 people attempting labor for a VBAC. Interestingly, they found that gestational week at birth was not linked to having a VBAC— whether someone gave birth at 37 weeks, 39 weeks, or 41 weeks—it didn’t make a difference to whether someone had a VBAC or a Cesarean birth after Cesarean.

    Q: Are there any benefits to going past your due date?

    A: One of the major benefits of going past your due date and awaiting the spontaneous start of labor is the hormonal benefit of experiencing spontaneous labor. In her book Hormonal Physiology of Childbearing (free full text available here), Dr. Sarah Buckley reviewed the research on the hormonal benefits of spontaneous labor.

    Based on the available evidence, Dr. Buckley concluded that:

    “Overall, consistent and coherent evidence from physiologic understandings and human and animal studies finds that that the innate, hormonal physiology of mothers and babies—when promoted, supported, and protected—has significant benefits for both in childbearing, and likely into the future, by optimizing labor and birth, newborn transitions, breastfeeding, maternal adaptations, and maternal-infant attachment” (Executive Summary, page 9).

    Another benefit of going past your due date and experiencing spontaneous labor is that you can avoid the potential risks of a medical induction, which may include experiencing a failed induction (possibly leading to a Cesarean), uterine tachysystole (uterine contractions that are too close together and may decrease blood flow to the baby), and adverse effects of other interventions that often occur with an induction, such as epidural anesthesia and continuous fetal monitoring (NICE 2021).

    Anecdotally it has been said that late- and post-term babies have an easier time with breastfeeding. While there is not much research on the subject, a recent study did examine the relationship with gestational age at birth and breastfeeding outcomes among women who were induced at different points at the end of pregnancy. This New Zealand study (Carlhäll et al. 2024) of 1,087 women compared labor and neonatal outcomes based on when an induction took place. In terms of timing, 266 participants had an induction at early term (37-38 weeks), 480 at full term (39-40 weeks), and 341 at late term (41 weeks or later). The researchers found that the rate of exclusive breastfeeding at discharge increased with increasing gestational age at birth, from 67.2% of those induced at early term, 76.4% of those induced at full term, and 81.4% of those induced at late term. However, only the women induced at late term were more likely to exclusively breastfeed after taking into account, age, BMI, whether this was someone’s first time giving birth, and the actual induction method.

    There may be cognitive benefits for babies when the pregnancy continues to 40-41 weeks (Murray et al. 2017). A study of Scottish schoolchildren found that the need for special education was highest among children born before 37 weeks (preterm babies), and then there was a continuous decrease in the need for special education until a low point at 41 weeks, after which the risk quickly rose again (MacKay et al. 2010). Middleton et al. (2020) in their review of the research did not find any studies that investigated the relationship between gestational age at birth and neurodevelopmental outcomes but identified this as an important area for future research.

    Q: Is it safe for someone to wait for labor to begin on its own, if that is what they prefer? How long is it safe to wait?

    A: When someone goes past their estimated due date, it is appropriate to talk with their care provider about the benefits and risks of elective induction and expectant management.

    Most research articles and guidelines say that because there are benefits and risks to both options, the pregnant person’s values, goals, and preferences should play a part in the decision-making process.

    It is important for expectant families to be aware of the growing research evidence showing worse health outcomes for those who wait for labor instead of being induced closer to 41 weeks 0 days, especially among first-time mothers and those with additional risk factors for stillbirth.

    Ultimately, after receiving accurate, evidence-based information and guidance from their health care provider, pregnant people have the right to decide whether they prefer to induce labor or wait for spontaneous labor with appropriate fetal monitoring.

    Q: How should people and their care providers talk about the risk of stillbirth?

    A: It can be difficult for health care providers and expectant parents to discuss the risk of stillbirth. Research on health care decision-making suggests that one of the best ways to frame the risk of stillbirth is to use the following techniques (Perneger & Agoritsas 2011; Fagerlin et al. 2011).

    1. Present risks in actual or “absolute” numbers (as opposed to relative risk)
    2. Talk about both potential gains and losses
    3. Offer a visual if possible
    4. Focus on the absolute difference between two risks

    So, using data from Muglu et al. (2019) in a real-life situation, this might look like:

    “At 41 weeks, out of 10,000 pregnant people, about 17 will have a stillbirth. This means 9,983 won’t have a stillbirth.

    In comparison, at 42 weeks, out of 10,000 pregnant people, about 32 will have a stillbirth. This means 9,968 won’t have a stillbirth. Here is a picture to help give you an idea of what this means.

    So, an extra 15 people out of 10,000 might avoid a stillbirth by being induced at 41 weeks. For the other 9,985 women, it won’t make a difference.”

    Then circle/highlight the additional 15 to show the difference.

    What do the guidelines say?

    As a pregnancy approaches 41 weeks (late-term), most professional guidelines begin to recommend that providers have discussions with patients about the benefits and risks of inducing labor versus expectant management (ACOG 2014, reaffirmed 2024; AOM 2021; Delaney & Roggensack 2017; NICE 2021). They also begin to recommend increased fetal monitoring if expectant management is chosen at 41 weeks and beyond. The recommendations for pregnancy at 42 weeks trend towards recommending induction if labor has not yet started on its own. If expectant management is chosen at 42 weeks and later in pregnancy, regular fetal monitoring is encouraged. In Table 4, we summarize some of the professional guidelines on this subject.

    Table 4: Professional Guidelines Recommendations for Inducing at 41 Weeks or Later

    Professional Guidelines Recommendations for Inducing at 41 Weeks or Later, at a glance

    Professional Organization

    Year of Publication

    Recommendations:

     

    American College of Obstetricians and Gynecologists (USA)

    2025, 2014

    ·         Before 41 weeks: Patients should receive counseling from their provider regarding the benefits and risks of induction of labor at or beyond 39 weeks compared with expectant management.

    ·         At 41 weeks: Induction of labor between 41 weeks and 42 weeks can be considered. Routine fetal monitoring should be introduced starting at 41 weeks.

    ·         At 42 weeks: Induction of labor after 42 weeks and by 42 weeks 6 days is recommended, given evidence of an increase in complications that can lead to stillbirth or negative health outcomes for the baby.

    American College of Nurse-Midwives (USA)

    2025, 2022

    ·         In general: Recommends that midwives use evidence-based tools to guide informed choice and support shared decision-making with patients about induction. Informed consent prior to labor induction should include a discussion of the process of labor and the benefits and potential harms of induction.

    ·         ACNM does not make a specific recommendation on induction at 41 or 42 weeks.

    Society of Obstetricians and Gynaecologists of Canada (Canada)

    2017

    ·         Before 41 weeks: Women should be offered the option of membrane sweeping to initiate labor between 38 to 41 weeks, following a discussion of risks and benefits.

    ·         At 41 weeks: Women should be offered induction at 41 to 42 weeks. Tests used to monitor the status of a 41- to 42-week pregnancy should include at least a non-stress test and an assessment of amniotic fluid volume.

    Association of Ontario Midwives (Canada)

    2021

    ·         Before 41 weeks: Prior to 41 weeks, midwives should discuss the risks and benefits of induction of labor between 41 and 42 weeks.

    ·         At 41 weeks: Midwives should offer IOL between 41+0 and 42+0 weeks. Midwives should offer clients with uncomplicated late term pregnancies full support in choices that allow them to maximize their chances of spontaneous labor, including supporting their decision to choose expectant management up to and beyond 41+0 weeks. Midwives should offer those who choose expectant management an ultrasound twice weekly, starting between 41 and 42 weeks and continuing until birth to assess fetal well-being.

    ·         At 42 weeks: For clients who choose expectant management after 42 weeks, midwives should discuss that the evidence suggests that risks of poor outcomes for the baby increase with gestational age, although absolute risks remain low.

    National Institute for Health and Care Excellence (UK)

    2021

    ·         At 41 weeks: Provider should explain that some risks associated with a pregnancy continuing beyond 41+0 weeks may increase over time, including risk of Cesarean birth, admission to NICU, or stillbirth. Provider should explain that induction could lower these risks. After discussion, provider should record pregnant person’s decision and continue with care (expectant management, induction, or Cesarean).

    ·         At 42 weeks: If a person has not gone into labor on their own at 42 weeks and beyond and does not want to have an induction, the provider should offer additional fetal monitoring  and discuss the risk of adverse outcomes with the pregnant person.

    What’s the bottom line on induction versus waiting for labor at 41 and 42 weeks?

    Elective induction at 41 weeks and 0 days or earlier could help to reduce stillbirths and poor health outcomes for babies, especially among first-time mothers. Importantly, two large randomized, controlled trials published in 2019 both found benefits to elective induction in the start of the 41st week of pregnancy instead of continuing to wait for labor until 42 weeks. One of the studies found fewer perinatal deaths with 41-week induction and the other found fewer poor health outcomes for babies (e.g., intensive care unit admission, low Apgar scores) with 41-week induction. Neither trial found an increase in the risk of Cesarean or forceps/vacuum during birth with 41-week induction compared to continuing to wait for labor until 42 weeks. Both of these trials took place in countries that follow the Midwifery Model of Care, and the overall Cesarean rates were low (only 10-11%).

    An earlier study called the Hannah Post-Term study found that waiting for labor after 41 weeks and 4 days greatly increased the risk of Cesarean for people who ended up needing an induction for medical reasons, but not for people who went into labor on their own. Some studies have found that expectant management was associated with a lower risk of Cesarean (Bruinsma et al. 2022; Källén et al. 2025), but the overall trend suggests that inductions are associated with a slight decrease in Cesarean births (Middleton et al. 2020).

    People can talk with their care providers about the pros and cons of waiting for spontaneous labor or elective induction at 41-42 weeks (see Table 2 in this article). This conversation should consider the mother’s preferences, personal birth history, risk factors for stillbirth, chances of a successful induction (how “ripe” the cervix is, also known as the Bishop score”), the facility’s Cesarean rate with induction, and alternatives.

    Some studies have looked at birthing people’s experiences and preferences. These non-medical factors are important when it comes to individual decision-making. For example, the experience of being induced (potentially more painful contractions, hooked up to wires for monitoring and IV fluids, and possibly confined to bed) may not make much of a difference to someone planning a birth with an epidural, but it can make a huge difference to someone planning to use movement and other comfort measures during an unmedicated birth. On the other hand, someone who has experienced miscarriages or stillbirth in the past may have a strong preference for elective induction in order to lower the absolute risk of stillbirth by any means necessary. All of these experiences and preferences are valid.

    References:
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    Acknowledgment

    We would like to extend our sincere thanks to Anna Bertone, MPH, for her input in a previous version of this article. We’d also like to thank those who reviewed a previous version—Charlotte Marie Shilo-Goudeau, LM, CPM, Evidence Based Birth® Instructor, Maternal Advisor, Birth Companion, Human Rights Advocate; Meredith Wallis, CNM, ANP, IBCLC; and Shannon J. Voogt, MD, Board-Certified in Family Medicine.

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